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Clinical Reviews in Allergy

, Volume 7, Issue 2, pp 141–163 | Cite as

Regulation of IgE Synthesis

Lymphocyte Fcɛ Receptor, IgE Binding Factor(s), and Giycosylation-Modulating Factors
  • Junji Yodoi
  • Takumi Kawabe
  • Masaaki Takami
Article
  • 24 Downloads

Conclusion

The importance of FcεR2/LgE-BF system on the IgE regulation has been clarified in both human as well as rodents. Recent cloning of human low affinity FcεR (FcεR2) will help us to clarify the dynamic regulatory mechanism of IgE regulation. The unique lectin-like molecular property of human FcεR2 and its variable expression on hematopietic cell lineages including T, B lymphocytes, monocytes, and eosinophils may indicate the multiple functions of this receptor system.

In the context of the IgE regulation by humanT cells, an interesting question is whether all the IgE-BFs from T cells (59, 60) are the products of this FcεR2 gene or not. The possible regulatory effects of the natural ligand of FcεR2, IgE, lymphokines including various interleukins, γIFN, SFA (4, 6), and Inducers of IgE-BF on the expression and processing of FcεR2 gene products are to be clarified.

Keywords

Peripheral Blood Lymphocyte Clinical Review Mesenteric Lymph Node Allergy Volume RPMI8866 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press, Inc 1989

Authors and Affiliations

  • Junji Yodoi
    • 1
  • Takumi Kawabe
    • 1
  • Masaaki Takami
    • 1
  1. 1.Faculty of Medicine, Institute for Immunology 1Kyoto UniversityKyotoJapan

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