Genetic susceptibility to lead poisoning—A case report

  • Anita R. Bijoor
  • T. Venkatesh
Case Report


Lead poisoning is well documented in persons occupationally exposed to lead. What is less known is, that even in persons working in lead based industries, the effect of lead and the appearance of signs and symptoms of lead poisoning is genetically determined. Three genes related to lead metabolism, exhibiting polymorphism have already been demonstrated-δALA-dehydratase, Vitamin D receptor gene and Hemochromatosis gene. These alleles determine the susceptibility of the individuals to lead. We present here a case of a lead acid battery worker, who presented without any signs and symptoms of lead poisoning except for a very high level of blood lead (82.8μg/dl and 47.5μg/dl 9 months later)

Key words

Lead poisoning Gene polymorphism Alleles 


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Copyright information

© Association of Clinical BIochemists of India 2007

Authors and Affiliations

  • Anita R. Bijoor
    • 1
  • T. Venkatesh
    • 1
  1. 1.Department of Biochemistry & BiophysicsSt. John's National Academy of Health SciencesBangalore

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