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Indian Journal of Clinical Biochemistry

, Volume 21, Issue 1, pp 165–168 | Cite as

Impaired hypothalamic-pituitary-gonadal axis function in men with diabetes mellitus

  • M. Maneesh
  • H. Jayalakshmi
  • T A Singh
  • Amit Chakrabarti
Article

Abstract

In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24±0.21) in the age group 20–40 (30.6±4.7) years were selected. Twenty-five healthy men (BMI 23.85±0.25), in the same age group (29.5±4.8) served as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress. Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive body fat might have also contributed to low serum testosterone.

Key words

Diabetes Mellitus Testosterone Hypothalamic-pituitary-gonadal axis Oxidative stress 

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Copyright information

© Association of Clinical Biochemists of India 2006

Authors and Affiliations

  • M. Maneesh
    • 1
  • H. Jayalakshmi
    • 2
  • T A Singh
    • 2
  • Amit Chakrabarti
    • 3
  1. 1.Department of BiochemistryMelaka Manipal Medical CollegeManipal
  2. 2.Department of BiochemistrySikkim Manipal Institute of Medical SciencesGangtok
  3. 3.Department of PharmacologySikkim Manipal Institute of Medical SciencesGangtok

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