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Lipid peroxidation and antioxidant status in blood of rheumatoid arthritis patients

  • D. Vijayakumar
  • K. Suresh
  • S. Manoharan
Article

Abstract

The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced glutathione) and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects. Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis patients are more prone to free radical mediated oxidative damage.

Keywords

Rheumatoid arthritis lipid peroxidation antioxidants 

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Copyright information

© Association of Clinical Biochemists of India 2006

Authors and Affiliations

  1. 1.Department of Biochemistry, Faculty of ScienceAnnamalai UniversityTamilnaduIndia

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