Abstract
A number of epidemiologic studies has been published in recent years showing an increase risk of death from cancer in subjects with low plasma cholesterol levels. Although several authors proposed that hypocholesterolemia is predisposing factor for cancer development, no causative relation has been established so far and that it may be that low plasma cholesterol is secondary to malignant disease. Hence, the present study was undertaken to examine the lipid profile in children patients with leukemia and Hodgkin's disease in comparison with age matched controls. The study included 52 normal healthy controls and 105 patients with leukemia and Hodgkin's disease. Lipid profile included serum cholesterol, HDL & LDL cholesterol and triglycerides. Serum cholesterol, HDL & LDL cholesterol were found to be inversely associated with incidence of cancer, whereas triglycerides were significantly elevated in cancer patients. The inverse association between cancer and serum cholesterol may reflect a physiological response to early undiagnosed stages of cancer.
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Feinleib, M. (1983) Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res. 43, 2503–2507.
Kreger, B.E., Anderson, K.M., Schatzkui, A. and Splansky, G.L. (1992) Serum cholesterol levels, body mass index and the risk of colon cancer. Cancer 70, 1038–1043.
Rao, K.N., Kottapally, S., Eskander, E.D., Shinozuka, H., Dessi, S. and Pani, P. (1986) Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification. Br. J. Cancer 25, 305–310.
Dessi, S., Batetta, B., Anchisi, C. et al. (1992) Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130). Br. J. Cancer 66, 787–793.
Dessi, S., Batetta, B., Pulisci, D., Accogli, P., Pani, P. and Broccia, G. (1991) Total and HDL cholesterol in human hematologic neoplasms. Int. J. Hematol. 54, 483–486.
Gilbert, H.S. and Ginsberg, H. (1984) Hypocholesterolemia as a manifestation of disease activity in chronic myelogenous leukemia. Cancer 51, 1428–1433.
Reverter, J.C., Sierra, J., Marti Tutusaus, J.M., Montserrat, E., Granena, A. and Rozman, C. (1988) Hypocholesterolemia in acute myelogenous leukemia. Eur. J. Haematol. 41, 317–320.
Nomura, A.M., Stemmermann, G.N. and Chyon, P.H. (1991) Prospective study of serum cholesterol levels and large bowel cancer. J. Natl. Cancer Inst. 83, 1403–1407.
Umeki, S. (1993) Decrease in serum cholesterol levels in advanced lung cancer. Respiration 60(3), 178–181.
Avall-Lundqvist, E.H. and Peterson, C.O. (1996) Serum cholesterol and apolipoprotein B levels may reflect disease activity in ovarian cancer patients. Acta. Oncol. 35(8), 1007–1010.
Sigurd, V., Magnus, B., Gosta G. and Curt P. (1985) Hypocholesterolemia in malignancy due to elevated low density lipoprotein receptor activity in tumor cells: Evidence from studies inpatients with leukemia. The Lancet. 23, 1150–1154.
Silvia B., Donata S., Cecilia Z., Livio P., Giuseppe L. and Bruno G. (1996) Prognostic relevance of lipoprotein cholesterol levels in acute lymphocytic and non lymphocytic leukemia. Acta Haematol. 96, 24–28.
Friedewald, W.T., Levy, R.I. and Friedrickson, D.S. (1972) Estimation of the concentration of Low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499–502.
Musolino, C., Calabro, L., Bellomo, G., Cincotta, M., DiGiacomo, V., Pezzano, B., Rizzo, V., Guglielmo, S. and Alonci, A. (2002) Lipid profile in haematologic neoplasms. Recenti Prog. Med. 93(5), 298–301.
Fiorenza, A.M., Branchi, A. and Sommariva, D. (2000) Serum lipoprotein profile in patients with cancer. A comparison with non-cancer subjects. Int. J. of Clin. and Lab. Res. 30(3), 141–145.
Zyada, L.E., Hassan, H.T., Rees, J.K. and Ragab, M.H., (1990) The relationship between hypocholesterolemia and degree of maturation in acute myeloid leukemia. Hematol. Oncol. 8(1), 65–69.
Peterson, C., Vitol, S., Rudling, M., Blomgren, H. and Skoog, L. (1985) Hypocholesterolemia in cancer patients may be caused by elevated LDL receptor activities in malignant cells. Med Oncol Tumor Pharmacother. 2(3), 143–147.
Budd, D. and Ginsberg, H. (1986) Hypocholesterolemia and acute myelogenous leukemia. Cancer 58, 1361–1365.
Pandolfino, J., Hakimian, D., Rademaker, A.W. and Tallman, M.S. (1997) Hypocholesterolemia in hairy cell leukemia: a marker for proliferative activity. Am. J. Haematol. 55(3), 129–133.
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Naik, P.P., Ghadge, M.S. & Raste, A.S. Lipid profile in leukemia and Hodgkin's disease. Indian J Clin Biochem 21, 100–102 (2006). https://doi.org/10.1007/BF02912921
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DOI: https://doi.org/10.1007/BF02912921