Summary
The glomerulus of normal and Masugi-nephritic rabbits was studied by scanning electron microscopy. The fundamental structure of the podocyte was essentially the same as that of rats and man. It was characteristic in rabbits that broad cytoplasmic sheets were frequently extended from the cell bodies, which might correspond to “podocytic membrane (Elias)” seen in transmission electron microscopy. In Masugi nephritis of rabbits the podocytes revealed increase in number, irregular arrangement and atrophy of the cytoplasmic processes, and increase of microprojections, which were assumed to be secondary reactions to proliferative glomerulonephritis. The terminal processes were preserved in large parts of glomeruli, although they were irregularly either atrophied or swollen.
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References
Arakawa, M.: A scanning electron microscopy of the glomerulus of normal and nephrotic rats. Lab. Invest.23, 489–496 (1970)
Arakawa, M.: A scanning electron microscope study of the human glomerulus. Amer. J. Path.64, 457–462 (1971)
Arakawa, M., Tokunaga, J.: A scanning electron microscope study of the glomerulus. Further consideration of the mechanism of the fusion of podocyte terminal processes in nephrotic rats. Lab. Invest.27, 366–371 (1972)
Buss, H., Krönert, W.: Zur Struktur des Nierenglomerulum der Ratte: rasterelektronen-mikroskopischer Untersuchungen. Virchow Arch. Abt. B4, 79–92 (1969)
Buss, H., Lamberts, B. H.: Orthology and pathology of the renal podocytes. Scanning Electron Microscopy/ 1972, Proceedings of the Part I: 5th Annual Scanning Electron Microscope Symposium and Part II: Workshop on Biological Specimen Preparation for Scanning Electron Microscopy (eds. Johari, O. and Corvin, I.), p. 574–580. Chicago: I.I.T. Research Institute 1972
Elias, H., Allara, E., Elias, P. M., Krishna Murthy, A. S.: The podocytes, re-examined. Z. mikr.-anat. Forsch.72, 344–365 (1965)
Elias, H., Pauly, J. E.: Human microanatomy, Philadelphia: F. A. Davis 1966
Fujimoto, T.: Histopathologic study of masugi nephritis. The mode of development of the glomerular changes. Acta path. jap.4, 1–19 (1954)
Fujimoto, T., Okada, M., Kondo, Y., Tada, T.: The nature of Masugi nephritis. Histo- and immunopathological studies. Acta path. jap.14, 275–310 (1964)
Fujita, T., Tokunaga, J., Miyoshi, M.: Scanning electron microscopy of the podocytes of renal glomerulus. Arch. Histol. Jap.32, 99–113 (1970)
Germuth, F. G., Jr., Rodrigez, E.: Immunopathology of the renal glomerulus. Immune complex deposit and antibasement membrane disease. Boston: Little, Brown & Co. 1973
Masugi, M.: Über das Wesen der spezifischen Veränderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Zugleich ein Beitrag zur Pathogenese der Glomerulonephritis und der eklamptischen Lebererkrankung. Beitr. path. Anat.91, 82–112 (1933)
Masugi, M.: Über die experimentelle Glomerulonephritis durch das specifische Antinierenserum. Ein Beitrag zur Pathogenese der diffusen Glomerulonephritis. Beitr. path. Anat.92, 429–466 (1934)
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Arakawa, M., Tokunaga, J., Shimotori, T. et al. A scanning electron microscope study of the glomerulus of normal and nephritic rabbits. Virchows Arch. B Cell Path. 17, 185–194 (1975). https://doi.org/10.1007/BF02912847
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DOI: https://doi.org/10.1007/BF02912847