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Virchows Archiv B

, Volume 17, Issue 1, pp 185–194 | Cite as

A scanning electron microscope study of the glomerulus of normal and nephritic rabbits

  • Masaaki Arakawa
  • Junichi Tokunaga
  • Takashi Shimotori
  • Yasutami Kinoshita
Article
  • 17 Downloads

Summary

The glomerulus of normal and Masugi-nephritic rabbits was studied by scanning electron microscopy. The fundamental structure of the podocyte was essentially the same as that of rats and man. It was characteristic in rabbits that broad cytoplasmic sheets were frequently extended from the cell bodies, which might correspond to “podocytic membrane (Elias)” seen in transmission electron microscopy. In Masugi nephritis of rabbits the podocytes revealed increase in number, irregular arrangement and atrophy of the cytoplasmic processes, and increase of microprojections, which were assumed to be secondary reactions to proliferative glomerulonephritis. The terminal processes were preserved in large parts of glomeruli, although they were irregularly either atrophied or swollen.

Key words

Scanning Electron Microscopy Glomerulus Masugi Nephritis 

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References

  1. Arakawa, M.: A scanning electron microscopy of the glomerulus of normal and nephrotic rats. Lab. Invest.23, 489–496 (1970)PubMedGoogle Scholar
  2. Arakawa, M.: A scanning electron microscope study of the human glomerulus. Amer. J. Path.64, 457–462 (1971)PubMedGoogle Scholar
  3. Arakawa, M., Tokunaga, J.: A scanning electron microscope study of the glomerulus. Further consideration of the mechanism of the fusion of podocyte terminal processes in nephrotic rats. Lab. Invest.27, 366–371 (1972)PubMedGoogle Scholar
  4. Buss, H., Krönert, W.: Zur Struktur des Nierenglomerulum der Ratte: rasterelektronen-mikroskopischer Untersuchungen. Virchow Arch. Abt. B4, 79–92 (1969)Google Scholar
  5. Buss, H., Lamberts, B. H.: Orthology and pathology of the renal podocytes. Scanning Electron Microscopy/ 1972, Proceedings of the Part I: 5th Annual Scanning Electron Microscope Symposium and Part II: Workshop on Biological Specimen Preparation for Scanning Electron Microscopy (eds. Johari, O. and Corvin, I.), p. 574–580. Chicago: I.I.T. Research Institute 1972Google Scholar
  6. Elias, H., Allara, E., Elias, P. M., Krishna Murthy, A. S.: The podocytes, re-examined. Z. mikr.-anat. Forsch.72, 344–365 (1965)PubMedGoogle Scholar
  7. Elias, H., Pauly, J. E.: Human microanatomy, Philadelphia: F. A. Davis 1966Google Scholar
  8. Fujimoto, T.: Histopathologic study of masugi nephritis. The mode of development of the glomerular changes. Acta path. jap.4, 1–19 (1954)Google Scholar
  9. Fujimoto, T., Okada, M., Kondo, Y., Tada, T.: The nature of Masugi nephritis. Histo- and immunopathological studies. Acta path. jap.14, 275–310 (1964)PubMedGoogle Scholar
  10. Fujita, T., Tokunaga, J., Miyoshi, M.: Scanning electron microscopy of the podocytes of renal glomerulus. Arch. Histol. Jap.32, 99–113 (1970)PubMedGoogle Scholar
  11. Germuth, F. G., Jr., Rodrigez, E.: Immunopathology of the renal glomerulus. Immune complex deposit and antibasement membrane disease. Boston: Little, Brown & Co. 1973Google Scholar
  12. Masugi, M.: Über das Wesen der spezifischen Veränderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Zugleich ein Beitrag zur Pathogenese der Glomerulonephritis und der eklamptischen Lebererkrankung. Beitr. path. Anat.91, 82–112 (1933)Google Scholar
  13. Masugi, M.: Über die experimentelle Glomerulonephritis durch das specifische Antinierenserum. Ein Beitrag zur Pathogenese der diffusen Glomerulonephritis. Beitr. path. Anat.92, 429–466 (1934)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Masaaki Arakawa
    • 1
    • 2
    • 3
  • Junichi Tokunaga
    • 1
    • 2
    • 3
  • Takashi Shimotori
    • 1
    • 2
    • 3
  • Yasutami Kinoshita
    • 1
    • 2
    • 3
  1. 1.Division of Nephrology Department of MedicineKawasaki Medical SchoolKurashiki City, Okayama-kenJapan
  2. 2.Department of BacteriologyKyushu Dental CollegeJapan
  3. 3.Department of MedicineNiigata University School of MedicineJapan

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