Virchows Archiv B

, 17:159 | Cite as

Aurosomes in rabbit articular cartilage

  • A. F. Oryschak
  • F. N. Ghadially


Intra-articular injections of sodium aurothiomalate (Myochrysine) into rabbit knee joints produced lysosomes (aurosomes) of a characteristic morphology in the chondrocytes of articular cartilage. Such lysosomes are morphologically distinct from other lysosomes and those seen in joints injected with sodium thiomalate. With the aid of electron probe x-ray analysis, gold and phosphorus have been demonstrated in the aurosomes. Numerous coated vacuoles developed in chondrocytes from joints injected with sodium aurothiomalate. It is thought that these vacuoles were involved in the transport of a gold-protein complex and that the aurosomes evolved from the coalescence of such vacuoles with primary lysosomes.


Articular Cartilage Gold Deposit Gold Salt Single Membrane Sodium Aurothiomalate 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • A. F. Oryschak
    • 1
  • F. N. Ghadially
    • 1
  1. 1.Department of Pathology, University HospitalUniversity of SaskatchewanSaskatoonCanada

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