Virchows Archiv B

, Volume 36, Issue 1, pp 65–75 | Cite as

Patterns of regeneration in vessels of human diseased muscle and skin

An ultrastructural study
  • Ruth M. Ludatscher


Regenerating vessels from 36 muscle biopsies and 12 skin biopsies pertaining to patients with the clinical and histological diagnosis of dermatomyositis-polymyositis and other inflammatory myopathies were described ultrastructurally. The following characteristics of vascular regeneration were encountered : a) alternation of thin and thick endothelial cells, b) superimposed segments of endothelial cytoplasm with formation of twisted intercellular junctions, c) long and complex intraluminal endothelial projections, d) discontinuous and porous perivascular basement lamina or multilaminated basement lamina. Some vessels featured only two or three of the mentioned characteristics. Endothelial fenestrations were occasionally encountered in the skin capillaries and were an exception in the muscle capillaries. In the skin there were aspects suggesting that intercalation of perivascular cells in the regenerating endothelial wall may occur. Most capillaries were in the final stage of regeneration.

Key words

Regenerating vessels Dermatomyositis Ultrastructure 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aloisi M, Giacomin C, Tessari R (1970) Growth of elementary blood vessel in diffusion chambers I Process of formation and conditioning factors. Virchows Arch Abt B Zellpath 6:350–364Google Scholar
  2. Aloisi M, Schiaffino S (1971) Growth of elementary blood vessels in diffusion chambers II Electron microscopy of capillary morphogenesis. Virchows Arch Abt B Zellpath 8:328–341Google Scholar
  3. Baloh R, Cancilla PA, Kalianaraman K, Munsat T, Pearson CM, Rich R (1972) Regeneration of human muscle. A morphologic and histochemical study of normal and dystrophic muscle after injury. Lab Invest 26:319–328PubMedGoogle Scholar
  4. Banker BQ (1975) Dermatomyositis of childhood. Ultrastructural alterations of muscle and intramuscular blood vessels. J Neuropathol Exp Neurol 34:46–75PubMedCrossRefGoogle Scholar
  5. Carlson BM (1973) The regeneration of skeletal muscle. A review. Am J Anat 137:119–150CrossRefGoogle Scholar
  6. Chalkley HW, Algire GH, Morris HP (1946) Effect of the level of dietary protein on vascular repair in wounds. J Natl Cancer Inst 6:363–372Google Scholar
  7. Chou SM, Nonaka I (1977) Satellite cells and muscle regeneration in diseased human skeletal muscles. J Neurol Sci 34:131–145PubMedCrossRefGoogle Scholar
  8. Elfvin LG (1965) The ultrastructure of the capillary fenestrae in the adrenal medulla of the rat. J Ultrastruct Res 12:687–704PubMedCrossRefGoogle Scholar
  9. Fawcett DW (1963) Comparative observations on the fine structure of blood capillaries. In: The peripheral blood vessels, Williams and Wilkins Co, Baltimore, p 17Google Scholar
  10. Györkey F, Sinkovics JG, Min KW, Györkey P (1972) A morphologic study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Am J Med 53:148–157PubMedCrossRefGoogle Scholar
  11. Ludatscher RM, Stehbens WE (1969) Vesicles of fenestrated and non-fenestrated endothelium. Z Zeilforsch 97:169–177CrossRefGoogle Scholar
  12. Ludatscher R, Gellei B, Guershoni G, Benderley A (1977) Small blood vessel involvement in childhood dermatomyositis. Isr J Med Sci 13:20–25PubMedGoogle Scholar
  13. Ludatscher RM (1978) Ultrastructure of human dermal blood vessels with special reference to the endothelial filaments. Virchows Arch Abt B Zellpath 27:347–357Google Scholar
  14. Majno G (1965) Ultrastructure of the vascular membrane. In: Handbook of physiology, vol 3, Sec 2. Am Physiol Soc, Washington DC, p 2293Google Scholar
  15. Matsuhashi K (1961) Electron microscopic observations of the corneal vascularization. J Clin Ophthalmol 15:121–127Google Scholar
  16. McKinney RV, Panner BJ (1972) Regenerating capillary basement membrane in skeletal muscle wounds: ultrastructural and histochemical study. Lab Invest 26:100–113PubMedGoogle Scholar
  17. McKinney RV Jr (1976) The structure of scorbutic regenerating capillaries in skeletal muscle wounds. Microvasc Res 11:361–379PubMedCrossRefGoogle Scholar
  18. McKinney RV Jr, Singh BB, Brewer PD (1977) Fenestrations in regenerating skeletal muscle capillaries. Am J Anat 150:213–218PubMedCrossRefGoogle Scholar
  19. Rhodin JAG (1962) The diaphragm of capillary endothelial fenestrations. J Ultrastruct Res 6:171–185PubMedCrossRefGoogle Scholar
  20. Rhodin JAG (1968) Ultrastructure of mammalian venous capillaries, venules and small collecting veins. J Ultrastruct Res 25:452–500PubMedCrossRefGoogle Scholar
  21. Sato T, Walker DL, Peters HA, Reese HH, Chou SM (1971) Chronic polymyositis and myxoviruslike inclusions. Arch Neurol 24:409–411PubMedGoogle Scholar
  22. Schoefl GI (1963) Studies on inflammation III Growing capillaries: their structure and permeability. Virchows Arch path Anat 337:97–141CrossRefGoogle Scholar
  23. Stehbens WE, Ludatscher RM (1968) Fine structure of senile angiomas of human skin. Angiology 19:581–592PubMedCrossRefGoogle Scholar
  24. Vracko R, Benditt EP (1972) Basal lamina: the scaffold for orderly cell replacement. Observation of injured skeletal muscle fibers and capillaries. J Cell Biol 55:406–419PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Ruth M. Ludatscher
    • 1
  1. 1.Department of PathologyThe Technion Faculty of Medicine and Rambam Medical CenterBat Galim, HaifaIsrael

Personalised recommendations