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Journal of Tongji Medical University

, Volume 6, Issue 1, pp 6–10 | Cite as

Studies on the calcium antagonistic action of tetrandrine: XIII. Protective effect of tetrandrine on myocardial hypoxia and necrosis induced by isoproterenol in rats

  • Fang Da-chao
  • Yang Xiao-ming
  • Jiang Ming-xing
Article

Summary

The protective effect of tetrandrine (Tet) on myocardial hypoxia and necrosis induced by isoproterenol (Iso) in rats has been investigated.

After administration of Iso (3 mg/kg s.c.), electrographical changes within 48 h were examined at first.

In the acute experiment, Tet (100 mg/kg s.c.) reduced the depression of T wave and SαT segment due to myocardial hypoxia induced by Iso (3 mg/kg s.c.). In subacute experiment, the electrographical changes of myocardial injury and necrosis caused by Iso (5 mg/kg s.c. sx2), inversion or biphasic pattern of T waves, elevation of SαT and the appearance of Q (q) wave were all alleviated by Tet too.

It was suggested that as a calcium antagonist Tet had a protective effect on myocardial hypoxia and necrosis induced by Iso in rats through blocking calcium influx into the cell.

Key words

tetrandrine isoproterenol myocardial hypoxia isoproterenol induced myocardial necrosis 

Über die Calcium-antagonistische Wirkung von Tetrandrin: XIII. Die Schutzwirkung von Tetrandrin auf die durch Isoproterenol hervorgerufene Hypoxie und Nekrose des Myokards der Ratte

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Copyright information

© Springer 1986

Authors and Affiliations

  • Fang Da-chao
    • 1
  • Yang Xiao-ming
    • 1
  • Jiang Ming-xing
    • 1
  1. 1.Department of PharmacologyTongji Medical UniversityWuhan

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