Osteoporosis in a boy with hypogonadotropic hypogonadism

  • Madoka Arisaka
  • Osamu Arisaka
  • Atsuto Hosaka
  • Akifumi Tokita
  • Naoto Shimura
  • Keijiro Yabuta
  • Yoshindo Kawaguchi
Original Articles


We describe a 16-year-old boy with idiopathic hypogonadotropic hypogonadism associated with osteoporosis. Osteoporotic lesions of the hands, skull and spine were shown by routine radiography. Single-photon absorptiometry at the distal radius confirmed a significant reduction of bone mineral density. The parathyroid hormone-vitamin D axis and calcitonin secretion showed no derangement. Reduced bone mineral density in association with relatively elevated levels of serum osteocalcin and alkaline phosphatase suggested an increased bone turnover (so-called high-turnover osteoporosis). Tetosterone therapy for 3 months significantly increased the radial bone mineral density.

This case illustrates that testosterone deficiency during puberty seems to alter the bone mineral status, impairing bone mineralization and bone remodeling.


Bone Mineral Density Osteoporosis Testosterone Bone Mineral Content Hypogonadism 
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Copyright information

© Japanese Society of Bone Metabolism Research 1989

Authors and Affiliations

  • Madoka Arisaka
    • 1
  • Osamu Arisaka
    • 1
  • Atsuto Hosaka
    • 1
  • Akifumi Tokita
    • 1
  • Naoto Shimura
    • 1
  • Keijiro Yabuta
    • 1
  • Yoshindo Kawaguchi
    • 2
  1. 1.Department of Pediatrics, JuntendoUniversity School of MedicineTokyoJapan
  2. 2.The Second Division, Department of Internal MedicineThe Jikei University School of MedicineTokyo

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