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Biological Trace Element Research

, Volume 42, Issue 3, pp 253–257 | Cite as

Accumulation of platinum in the intervertebral discs and vertebrae of ovarian tumor-bearing patients treated with cisplatin

  • Takeshi Minami
  • Kouji Hashii
  • Ichiro Tateyama
  • Eizi Kadota
  • Yoshiyuki Tohno
  • Setsuko Tohno
  • Masako Utsumi
  • Masa-Oki Yamada
  • Masayo Ichii
  • Kiyohiro Namikawa
  • Yuko Okazaki
Article

Abstract

Platinum was determined by the inductively coupled plasma mass spectrometry (ICP-MS) in the intervertebral discs and vertebrae of ovarian tumor bearing patients treated withcis-diamminedichloro-platinum (II) (cisplatin). Platinum was 0.05 ng/mL at the absolute detection limit, and platinum was undetectable in the intervertebral discs and vertebrae of human specimens without cisplatin treatments. On the other hand, platinum was detected in the intervertebral discs and vertebrae of patients administered cisplatin, and platinum concentration was at levels of 1.06–10.31 μg/g dry tissue in the intervertebral discs and 0.60–1.28 μg/g dry tissue in the vertebrae, respectively. The platinum level of intervertebral discs was 4.3-fold higher than that of the vertebrae.

Thus, platinum accumulates greatly in the intervertebral discs and somewhat in the vertebrae after administering cisplatin to patients for therapy.

Index Entries

Cisplatin platinum intervertebral disc vertebra ovarian tumor therapy ICP-MS 

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Copyright information

© Human Press Inc 1994

Authors and Affiliations

  • Takeshi Minami
    • 1
  • Kouji Hashii
    • 2
  • Ichiro Tateyama
    • 2
  • Eizi Kadota
    • 3
  • Yoshiyuki Tohno
    • 4
  • Setsuko Tohno
    • 4
  • Masako Utsumi
    • 4
  • Masa-Oki Yamada
    • 4
  • Masayo Ichii
    • 1
  • Kiyohiro Namikawa
    • 1
  • Yuko Okazaki
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKinki UniversityOsakaJapan
  2. 2.Division of GynecologyKishiwada Municipal HospitalOsakaJapan
  3. 3.Division of PathologyKishiwada Municipal HospitalOsakaJapan
  4. 4.Department of AnatomyNara Medical UniversityNaraJapan

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