Summary
It has been shown that gentamycin incorporated into polymethylmethacrylate (TJ bone cement or O-PMMA) can be released in the body. It can be continuously set free into the surroundings in therapeutic concentration in vivo for at least 10 months and inhibit several kinds of pathogenic bacteria for a prolonged period of time, e.g., Staphylococcus aureus for 300 days. It does not influence mechanical strength of TJ bone cement when 1 g of gentamycin powder is added to 20 g of cement. The present study offers a theoretical basis for the prevention of sepsis following artificial joint replacement and for the treatment of chronic osteomyelitis with domestic gentamycin-PMMA. A gentamycin-PMMA chain has been successfully made.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
1980;18:258–61.
1981;5: 285–6.
Elson RA, et al. Antibiotic-loaded acrylic cement. J Bone Joint Surg 1977;59(B): 200–5.
Andrews HJ, et al. Deep infection after total hip replacement. J Bone Joint Surg 1981; 63(B): 53–7.
Marks KE, et al. Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg 1976;58(A): 358–64.
Hill, et al. Diffusion of antibiotics from acrylic bone cement in vitro. J Bone Joint Surg 1977;59(B): 197–9.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
An-min, C., Tai-yi, W. & Zhen-fan, L. Experimental study on gentamycin-loaded polymethylmethacrylate. Journal of Tongji Medical University 6, 167–171 (1986). https://doi.org/10.1007/BF02911455
Issue Date:
DOI: https://doi.org/10.1007/BF02911455