Journal of Tongji Medical University

, Volume 6, Issue 3, pp 167–171 | Cite as

Experimental study on gentamycin-loaded polymethylmethacrylate

  • Chen An-min
  • Wang Tai-yi
  • Li Zhen-fan


It has been shown that gentamycin incorporated into polymethylmethacrylate (TJ bone cement or O-PMMA) can be released in the body. It can be continuously set free into the surroundings in therapeutic concentration in vivo for at least 10 months and inhibit several kinds of pathogenic bacteria for a prolonged period of time, e.g., Staphylococcus aureus for 300 days. It does not influence mechanical strength of TJ bone cement when 1 g of gentamycin powder is added to 20 g of cement. The present study offers a theoretical basis for the prevention of sepsis following artificial joint replacement and for the treatment of chronic osteomyelitis with domestic gentamycin-PMMA. A gentamycin-PMMA chain has been successfully made.

Key word

gentamycin-PMMA artificial joint infection osteomyelitis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    1980;18:258–61.Google Scholar
  2. 2.
    1981;5: 285–6.Google Scholar
  3. 3.
    Elson RA, et al. Antibiotic-loaded acrylic cement. J Bone Joint Surg 1977;59(B): 200–5.Google Scholar
  4. 4.
    Andrews HJ, et al. Deep infection after total hip replacement. J Bone Joint Surg 1981; 63(B): 53–7.Google Scholar
  5. 5.
    Marks KE, et al. Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg 1976;58(A): 358–64.PubMedGoogle Scholar
  6. 6.
    Hill, et al. Diffusion of antibiotics from acrylic bone cement in vitro. J Bone Joint Surg 1977;59(B): 197–9.Google Scholar

Copyright information

© Springer 1986

Authors and Affiliations

  • Chen An-min
    • 1
  • Wang Tai-yi
    • 1
  • Li Zhen-fan
    • 1
  1. 1.Department of Orthopedics, Tongji HospitalTongji Medical UniversityWuhan

Personalised recommendations