KLF6mRNA expression in primary hepatocellular carcinoma

  • Wang Shaoping
  • Chen Xiaoping
  • Zhang Wanguang
  • Qiu Fazu


To investigate the expression of KLF6mRNA in primary hepatocellular carcinoma (HCC), nomal liver tissues and the tissues adjacent to the cancers, reverse-transcription polymerase chain reaction (RT-PCR) was employed to investigate the expression of the KLF6 gene in HCC, the corresponding adjacent non-cancerous tissues and normal liver tissue. Our results showed that an amplified fragment of 127 bp DNA was detected in 18 of 19 (94.7%) adjacent non-cancerous tissues and normal liver tissue, and in 12 (85.7%) of 11 HCC. There were no significant differences in the levels of KLF6 mRNA between normal liver and liver tumors (P>0.05). It is concluded that KLF6 mRNA is generally expressed in HCC.

Key words

Kruppel-like factor 6 (KLF6) hepatocellular carcinoma (HCC) reverse-transcription polymerase chain reaction (RT-PCR) 


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Copyright information

© Springer 2004

Authors and Affiliations

  • Wang Shaoping
    • 1
  • Chen Xiaoping
    • 1
  • Zhang Wanguang
    • 1
  • Qiu Fazu
    • 1
  1. 1.Hepatic Surgery Center, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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