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Journal of Tongji Medical University

, Volume 9, Issue 4, pp 239–243 | Cite as

Wirkung der Lipoxygenase- und Cyclooxygenase-Metaboliten auf die akute hypoxische pulmonale Vasokonstriktion beim Schweinchen

  • Zou Ai-ping
  • Cheng Gang
  • Pi Ye-qin
  • Wang Wei-han
  • Yu Shang-bin
  • Wang Di-xun
Article

The role of lipoxygenase and cyclooxygenase metabolites in acute hypoxic pulmonary vasoconstriction in piglets

Zusammenfassung

Durch am Schweinchen durchgeführte Versuche wurde nachgewiesen, daß die akute alveoläre Hypox ie starke pulmonale Vasokonstriktion mit Erhöhung des Herzzeitvolumens hervorrufen kann. Die pulmonale vasokonstriktive Reaktion auf akute alveoläre Hypoxie wurde durch den Lipoxygenase-Inhibitor Diäthylkarbamazin nicht gehemmt, aber durch den Cyclooxygenase-Inhibitor Indomethacin erhöht. Es wird angenommen, daß die Lipoxygenase-Metabolite, die Leukotriene, die hypoxische pulmonale Vasokonstriktion (HPV) bei Schweinchen nicht vermitteln konnten, daß jedoch die Cyclooxygenase-Metabolite, die Prostaglandine, insbesondere die vasodilatatorischen Prostaglandine, die HPV modulieren konnten.

Abstract

The role of lipoxygenase and cyclooxygeriase metabolites in acute hypoxic pulmonary vasoconstriction (HPV) was studied in piglets, it has been found that acute alveolar hypoxia induced remarkable pulmonary vasoconstrion, associated with an increase in cardiac output. The hypoxic pulmonary vasoconstriction response was insignificantly attenuated after infusion of DEC. indomethacin potentiated mar kedly the increase in pulmonary artery pressure and pulmonary vascular resistance and thus augmented HPV. It is inferred that hypoxic pulmonary vsaoconstriction in piglet may be mediated by other important mediators in addition to leukotrienes, but modulated by prostaglandins to prevent an excessive rise in pulmonary artery pressure.

Schlüsselwörter

Hypoxie pulmonale Vasokonstriktion Leukotrien Prostaglandin Lipoxygenase Cyclooxygenase 

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Copyright information

© Springer 1990

Authors and Affiliations

  • Zou Ai-ping
    • 1
  • Cheng Gang
    • 1
  • Pi Ye-qin
    • 1
  • Wang Wei-han
    • 1
  • Yu Shang-bin
    • 1
  • Wang Di-xun
    • 1
  1. 1.Institut für PathophysiologieTongji Medizinische UniversitätWuhan

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