The expanding spectrum of clinical and laboratory features of IgE myeloma

Report of a case and review of the literature
  • Franco Dammacco
  • Antonio Miglietta
  • Maurizio Tribalto
  • Franco Mandelli
  • Lorenzo Bonomo
Original Contributions


A new case of IgE myeloma is described. Patient G.M., a 60-year-old woman, complained with a 3-months’ history of generalized bone pain, weight loss, profound weakness and severe anemia. A bone survey revealed multiple lytic lesions, and a heavy replacement by plasma cells was disclosed in the bone marrow examination of a sternal sample. In addition, an IgE serum M-component and γ-type Bence Jones proteinuria were identified by immunochemical studies. The disease course was rapid, death occurring within 6 months of clinical onset. A molecular weight of 188,500 daltons was calculated for the purified protein G.M., whereas the molecular weights of its subunits were found to be 72,000 for the ε chains and 43,000 for the γ chain dimers. This case is compared with 15 reported cases of IgE monoclonal gammapathy, an expanding clinical and laboratory spectrum emerging from the review of the literature.


Electrophoresis IgE myeloma Immunochemistry Immunoelectrophoresis Monoclonal gammapathy Proteins 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Franco Dammacco
    • 1
  • Antonio Miglietta
    • 1
  • Maurizio Tribalto
    • 2
  • Franco Mandelli
    • 2
  • Lorenzo Bonomo
    • 1
  1. 1.Istituto di Clinica Medica Generale e Terapia Medica IUniversità degli Studi di BariBariItalia
  2. 2.Cattedra di EmatologiaUniversità degli Studi di RomaItalia

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