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Medical Oncology

, Volume 16, Issue 3, pp 199–203 | Cite as

The role of neoadjuvant and adjuvant chemotherapy regimens consisting of different combinations of drugs in the treatment of advanced oral cancer

  • S Basu
  • M Khanra
  • B Dash
  • J Majumdar
  • J Biswas
  • P Chaudhuri
Original Paper

Abstract

We performed a retrospective analysis on the effect of neoadjuvant chemotherapy with three cycles of methotrexate (100 mg/m2 on day 1), cisplatin (90 mg/m2 on day 1) and bleomycin (20 mg/m2 on day 1–5) with 21 d gap between each cycle in 44 patients with advanced squamous cell carcinoma of the cheek, lip and tongue followed by surgery and adjuvant chemotherapy consisting of cisplatin (90 mg/m2 on day 1), Mitomycin C (6 mg/m2 on day 1) and 5-fluorouracil (1000 mg/m2 120 h continuous infusion from day 1) repeated every 3 weeks for three cycles.

Following induction chemotherapy, complete response was observed in 11 out of 44 patients (25%), and a partial response in a further 28 patients (64%).

The overall median survival of all patients was 29 months and those in stage III and stage IV were 30 and 15 months respectively (P<0.001). The median duration of the time to relapse in patients who responded to adjuvant chemotherapy was 28 months.

The main toxic effect was vomiting followed by hematological toxicity. No treatment-related deaths occurred.

The regimen showed a significant response, encouraging median survival and a good tolerability profile.

Keywords

oral cancer combination chemotherapy neoadjuvant adjuvant 

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Copyright information

© Stockton Press 1999

Authors and Affiliations

  • S Basu
    • 1
  • M Khanra
    • 1
  • B Dash
    • 1
  • J Majumdar
    • 2
  • J Biswas
    • 2
  • P Chaudhuri
    • 3
  1. 1.Department of Medical OncologyChittaranjan National Cancer InstituteCalcuttaIndia
  2. 2.Department of Surgical OncologyChittaranjan National Cancer InstituteCalcuttaIndia
  3. 3.Department of Radiation OncologyChittaranjan National Cancer InstituteCalcuttaIndia

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