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The concentration of u-PA and PAI-1 antigen in tissue extracts of nasopharyngeal carcinoma

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Abstract

We measured the antigen levels of urokinasetype plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in tissue extracts from nasopharyngeal carcinomas. An increase in u-PA antigen was observed with the advanced stages of disease. However, the levels of PAI-1 antigen decreased with each advanced stage. These results suggest that local administration of antiplasminic agents may be effective in suppressing tumor invasion.

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Authors and Affiliations

  1. 1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, 903-01, Okinawa, Japan

    M. Sunagawa & M. Nakamura

  2. 1st Department of Physiology and The Research Center of Comprehensive Medicine, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, 903-01, Okinawa, Japan

    T. Kosugi

  3. Department of Otorhinolaryngology, Guangxi Medical University, No. 6 Binhu Road, Nanning, 530027, Guangxi P.R., China

    G. W. Huang

Authors
  1. M. Sunagawa
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  2. G. W. Huang
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  3. M. Nakamura
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  4. T. Kosugi
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Sunagawa, M., Huang, G.W., Nakamura, M. et al. The concentration of u-PA and PAI-1 antigen in tissue extracts of nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol 254, 277–280 (1997). https://doi.org/10.1007/BF02905987

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  • DOI: https://doi.org/10.1007/BF02905987

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