The concentration of u-PA and PAI-1 antigen in tissue extracts of nasopharyngeal carcinoma

  • M. Sunagawa
  • G. W. Huang
  • M. Nakamura
  • T. Kosugi
Original Paper


We measured the antigen levels of urokinasetype plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in tissue extracts from nasopharyngeal carcinomas. An increase in u-PA antigen was observed with the advanced stages of disease. However, the levels of PAI-1 antigen decreased with each advanced stage. These results suggest that local administration of antiplasminic agents may be effective in suppressing tumor invasion.

Key words

Nasopharyngeal carcinoma Urokinasetype plasminogen activator Plasminogen activator inhibitor-1 Tumor invasion 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • M. Sunagawa
    • 1
  • G. W. Huang
    • 3
  • M. Nakamura
    • 1
  • T. Kosugi
    • 2
  1. 1.1st Department of Physiology, School of MedicineUniversity of the RyukyusOkinawaJapan
  2. 2.1st Department of Physiology and The Research Center of Comprehensive Medicine, School of MedicineUniversity of the RyukyusOkinawaJapan
  3. 3.Department of OtorhinolaryngologyGuangxi Medical UniversityGuangxi P.R.China

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