Pathology & Oncology Research

, Volume 4, Issue 4, pp 251–257 | Cite as

Diagnostics of multidrug resistance in cancer

  • Gergely SzakÁCs 
  • Katalin Jakab 
  • Ferenc Antal 
  • Balázs Sarkadi 


Multidrug resistance (MDR), caused by the overexpression of two membrane proteins, MDR1-Pgp and/or MRP, is a major obstacle in the chemotherapy of cancer. The proper laboratory diagnosis of clinical multidrug resistance is still an unresolved question, and this uncertainty, in a vicious cycle, does not allow the correct evaluation of the clinical relevance of the MDR phenomenon. Moreover, inefficient MDR diagnostics hinders the de velopment of effective resistance-modulation strategies. In this review, after describing the basic features of the MDR drug pump proteins, the currently employed diagnostic methods are discussed. We suggest that a quantitative, functional method developed in our laboratory may provide a major help in the laboratory assessment of cancer MDR.

Key words

P-glycoprotein MDR1 MRP multidrug transporters diagnostic methods 


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Copyright information

© Arányi Lajos Foundation 1998

Authors and Affiliations

  • Gergely SzakÁCs 
    • 1
    • 2
  • Katalin Jakab 
    • 1
    • 2
  • Ferenc Antal 
    • 1
    • 2
  • Balázs Sarkadi 
    • 1
    • 2
  1. 1.National Institute of Haematology and ImmunologyBudapestHungary
  2. 2.Membrane Research Group of the Hungarian Academy of SciencesBudapestHungary

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