Ricerca in clinica e in laboratorio

, Volume 14, Issue 2, pp 199–203 | Cite as

ACTH 1–17 effects in acute myeloid leukemia

  • William Arcese
  • Clara Nervi
  • Giuseppe Avvisati
  • Franco Mandelli
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We conducted a double blind randomized clinical study with 100 μg i.v. ACTH 1–17 versusplacebo in 40 consecutive acute myelocytic leukemia patients (AML). The same regimen 3+7 schedule, employing daunorubicin (DNR) associated with cytosine-arabinoside (ARA-C), was applied as remission induction therapy to all patients. Prednisone therapy was performed as necessary. Twenty patients, receiving ACTH 1–17, were compared with 20 other patients receivingplacebo in regard to remission rate, hemorrhagic and infective complications, remission duration and survival. No significant difference was observed between the 2 groups for all parameters taken into consideration. The two year actuarial curves of remission duration and survival showed a trend in favour of the ACTH 1–17 group. It needs a longer follow-up to evaluate if ACTH 1–17 will represent an effective adjuvant of the induction chemotherapy for the long-term control of the acute myelocytic leukemia.


ACTH 1–17 Acute myelocytic leukemia Circadian rhythms DNR and ARA-C 3+7 protocol 


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  1. 1.
    Cardoso S. S., Scheving L. E., Halberg F.: Mortality of mice as influenced by the hour of the day of drug (ara-c) administration—Pharmacologist12, 302, 1979.Google Scholar
  2. 2.
    Davies G. J. V., Mac Donald J., Halberg F., Simpson H. W.: Circadian rhythm in murine tolerance of daunorubicin—Lancetii, 779, 1974.CrossRefGoogle Scholar
  3. 3.
    Halberg F., Haus E., Cardoso S. S., Scheving L. E., Kühl J. F. W., Shiotsuka R., Rosene G., Pauly J. E., Runge W., Spalding J. F., Lee J. K., Good R. A.: Toward a chronotherapy of neoplasia: tolerance of treatment depends upon host rhythms—Experientia (Basel)24, 909, 1973.Google Scholar
  4. 4.
    Haus E., Halberg F., Scheving L. E., Pauly J. E., Cardoso S. S., Kühl J. F. W., Sothern R. B., Shiotsuka R. N., Shong Hwang D.: Increased tolerance of leukemic mice to arabinosyl cytosine with schedule adjusted to circadian system—Science177, 80, 1972.PubMedCrossRefGoogle Scholar
  5. 5.
    Hromas R. A., Hutchins Y. L., Markel D. E., Scholes V. E.: Flow cytometric analysis of the effect of ARA-C on the chronobiology of bone marrow DNA synthesis—Chronobiologia8, 369–373, 1981.PubMedGoogle Scholar
  6. 6.
    Levi F., Halberg F., Haus E., Sanchez de la Peña S., Sothern R. B., Halberg E., Hrushesky W., Brown H., Scheving L. E., Kennedy B. J.: Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for adriamycin—Chronobiologia7, 227–244, 1980.PubMedGoogle Scholar
  7. 7.
    Philippens K. M. H., Scheving L. E.: Chronotoxic and therapeutic effects of adriamycin in Ehrlich ascites tumor-bearing NMRI-mice—Chronobiologia6, 143, 1979. (abstract)Google Scholar
  8. 8.
    Rai K. R., Holland J. F., Glidewell O. J., Weinberg V., Brunner K., Obrecht J. P., Preisler H. D., Nawabi I. W., Pracer D., Carey R. W., Cooper M. R., Haurani F., Hutchinson J. L., Silver R. T., Falkson G., Wiernik P., Hoagland H. C., Bloomfield C. D., Watson J. G., Gottlieb A., Ramanan S. V., Blom J., Nissen N. I., Bank A., Ellison R. R., Kung F., Henry P., Ross McIntyre, Kaan S. K.: Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B—Blood58, (6), 1981.Google Scholar
  9. 9.
    Reinberg A., Guillemant S., Ghata N. J., Guillemant J., Touitou Y., Dupont W., Lagoguey M., Bourgeots Ph., Brière L., Fraboulet G., Guillet Ph.: Clinical chronopharmacology of ACTH 1–17. I. Effects on plasma cortisol and urinary 17-hydroxycorticosteroids—Chronobiologia7, 513, 1980.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • William Arcese
    • 1
  • Clara Nervi
    • 1
  • Giuseppe Avvisati
    • 1
  • Franco Mandelli
    • 1
  1. 1.Cattedra di EmatologiaUniversità degli Studi ‘La Sapienza’RomaItaly

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