Ricerca in clinica e in laboratorio

, Volume 14, Issue 3, pp 515–519 | Cite as

Abnormal reactivity with thrombin of a new variant of dysfunctional antithrombin (AT ‘Vicenza’)

  • Guido Finazzi
  • Tiziano Barbui
  • Tri H. Tran
  • François Duckert
III. Proteins Inhibiting Coagulation and Fibrinolysis


Antithrombin Antithrombin-thrombin complexes Familial antithrombin deficiency Familial thrombosis Thrombin 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abildcaard U., Lie M., Ødegard O. R.: A simple amidolytic method for the determination of functionally active antithrombin III—Scand J. clin. Lab. Invest.36, 109, 1976.CrossRefGoogle Scholar
  2. 2.
    Ambruso D. R., Leonard B. D., Bies R. D., Jacobson L., Hathaway W. E., Reeve E. B.: Antithrombin III deficiency: decreased synthesis of a biochemically normal molecule—Blood60, 78, 1982.PubMedGoogle Scholar
  3. 3.
    Barbui T., Finazzi G., Rodechiero F., Dini E.: Immunoelectrophoretic evidence of thrombin-induced abnormality in a new variant of hereditary dysfunctional antithrombin III (ATIII “Vicenza”.—Brit. J. Haematol.54, 561, 1983.CrossRefGoogle Scholar
  4. 4.
    Laurell, C. B.: Electroimmunoassay—Scand. J. clin. Lab. Invest.29 (Suppl. 124), 21, 1972.CrossRefGoogle Scholar
  5. 5.
    Ødegard O. R., Lie M., Abildgaard U.: Heparin cofactor, activity measured with an amidolytic method—Thrombos. Res.6, 287, 1975.CrossRefGoogle Scholar
  6. 6.
    Ødegard O. R., Lie M., Abildgaard U. Anti-factor Xa measured with amidolytic methods— Haemostasis5, 265, 1976.PubMedGoogle Scholar
  7. 7.
    Rodeghiero F., Barbui T.: Two-dimensional immunoelectrophoresis of antithrombin III during disseminated intravascular coagulation in acute leukemia—Thrombos. Res.12, 191, 1977.CrossRefGoogle Scholar
  8. 8.
    Sas G., Blaskó G., Bánhegyi D., Jákó J., Pálos L. A.: Abnormal antithrombin III (antithrombin III ‘Budapest’) as a cause of a familial thrombophilia—Thrombos. Diathes. haemorrh. (Stuttg.)32, 105, 1974.Google Scholar
  9. 9.
    Tran T. H., Bondeli C., Marbet G. A., Duckert F.: Reactivity of a hereditary abnormal antithrombin III fraction in the inhibition of thrombin and factor Xa—Thrombos. Haemost.44, 92, 1980.Google Scholar
  10. 10.
    Tran T. H., Bounameaux H., Bondeli C., Honkanen H., Marbet G. A., Duckert F.: Purification and partial characterization of a hereditary abnormal antithrombin III fraction of a patient with recurrent thrombophlebitis—Thrombos. Haemost.,44, 87, 1980.Google Scholar
  11. 11.
    Weber K., Osborn M.: The reliability of molecular weight determination by dodecylsulfate polyacrylamide gel electrophoresis—J. biol. Chem.244, 4406, 1969.PubMedGoogle Scholar
  12. 12.
    Wolf M., Boyer C., Lavergne J. M., Larrieu M. J.: A new familial variant of antithrombin III: ‘antithrombin III Paris’—Brit. J. Haematol.,51, 285, 1982.Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Guido Finazzi
    • 1
  • Tiziano Barbui
    • 1
  • Tri H. Tran
    • 2
  • François Duckert
    • 2
  1. 1.Divisione di EmatologiaOspedati Riuniti di BergamoBergamoItalia
  2. 2.Coagutation and Fibrinolysis LaboratoryKantonsspital BasleBasleSwitzerland

Personalised recommendations