Pathology & Oncology Research

, Volume 4, Issue 1, pp 48–51 | Cite as

Biclonal primary plasma cell leukemia

  • Zoltán TÓth
  • József Sipos
Case Report


Authors present a multiparameter pathological study in a case of rapid biclonal primary plasma cell leukemia. The immunohistochemical data revealed aberrant phenotypes (monocyte, epithelial and T-cell) probably in connection with microenvironmental influences. Biclonality can be attributed to class switching during malignant transformation. Static image cytometry showed aneuploidy. The blasts of this process are active immunoregulatory cells.

Key words

primary plasma cell leukaemia biclonality immunohistology image cytometry 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Berg AR, Weisenburger DD, Linder J et al: Lymphoplasmacytic Lymphoma. Cancer 57:1794–1797, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    Feinman R, Sawyer J, Hardin J et al: Cytogenetics and Molecular Genetics in Multiple Myeloma. Hematol/Oncol Clin North Amer 11: 1–25, 1997.CrossRefGoogle Scholar
  3. 3.
    Fülle HH, Pribilla W: Diagnose und Therapie der Plasmazellenleukemie. Dtsch med Wschr 98: 874–881, 1973.PubMedGoogle Scholar
  4. 4.
    Gerstein H, Budman DR, Schulman P et al: Biclonal IgM Gammopathy in a Lymphoproliferative Disorder. Cancer 52: 824–827, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    Guarner J, Austin GE, Nassar V: Biclonal Gammopathy (IgG and IgG) in a Patient With Non-Hodgkin’s Lymphoma. Arch Pathol Lab Med 110:445–448, 1986.PubMedGoogle Scholar
  6. 6.
    Kelényi G: Biology and pathology of plasma-cell tumors (In Hungarian). Magyar Belorvosi Archivum 1:32–38, 1997.Google Scholar
  7. 7.
    Lasota J, Hyjek E, Koo CH et al: Cytokeratin-positive Large-cell Lymphomas of B-cell Lineage. Amer J Surg Pathol 20:346–354, 1996.CrossRefGoogle Scholar
  8. 8.
    Leo E, Kropff M, Lindemanri A, et al: DNA Aneuploidy Increased Proliferation and Nuclear Area of Plasma Cells in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma. Anal Quant Cytol Histol 17: 113–119, 1995.PubMedGoogle Scholar
  9. 9.
    Menke D, Horny HP, Sebo T, et al: Use of Morphology, Immunophenotypic Aberrancy, Proliferation Indices, and Ploidy in the Prognostic Evaluation of Plasma Cell Neoplasms. Abstract. 84th Ann Meeting of US and Canad Acad Pathol, March 1117, 1995, Toronto. Modern Pathol 8: 116A, 1995.Google Scholar
  10. 10.
    Munshi NC: Immunoregulatory Mechanisms in Multiple Myeloma. Hematol/Oncol Clin North Amer 11: 51–69, 1997.CrossRefGoogle Scholar
  11. 11.
    Nishimoto 11T Shima Y, Yoshizaki K, et al: Myeloma Biology and Therapy. Hematol/Oncol Clin North Amer 11: 159–172, 1997.CrossRefGoogle Scholar
  12. 12.
    Pellegrini W, Facchetti F, Marocolo D et al: Assessment of cell proliferation in normal and pathological bone marrow biopsies: a study using double sequental immunophenotyping on paraffin sections. Histopathology 27: 397–405, 1995.PubMedCrossRefGoogle Scholar
  13. 13.
    Petruch UR, Horny HP, Kaiserling E: Frequent expression of haemopoietic and non-haemopoietic antigens by neoplastic plasma cells: an immunohistochemical study using formalin-fixed, paraffin-embedded tissue. Histopathology 20:35–40, 1992.PubMedCrossRefGoogle Scholar
  14. 14.
    Schaffner KF’, Krause JR, Kelly RH: Biclonal IgM Gammopathy in Chronic Lymphocytic Leukemia. Arch Pathol Lab Med 112:206–208, 1988.PubMedGoogle Scholar
  15. 15.
    Skopelitou A, Tselenis S, Theocharis S: Expression of Proliferating Cell Nuclear Antigen (PCNA) and Nucleolar Organizer Regions (NORs) in Multiple Myeloma. Anticancer Res 14: 787–792, 1994.PubMedGoogle Scholar
  16. 16.
    Teoh G, Anderson K: Interaction of Tumor and Host Cells With Adhesion and Extracellular Matrix Molecules in the Development of Multiple Myeloma. Hematol/Oncol Clin North Amer 11: 27–42, 1997.CrossRefGoogle Scholar
  17. 17.
    Yatable Y, Mori N, Oka K et al: A Case With Primary Gastric Lymphoma Producing IgM and IgG Immunoglobulins. Arch Pathol Lab Med 118:655–658, 1994.Google Scholar
  18. 18.
    Yi Q, Dabadhghao S, Österborg A et al: Myeloma Bone Marrow Plasma Cells: Evidence for Their Capacity as Antigen-Presenting Cells. Blood 90: 1960–1967, 1997PubMedGoogle Scholar
  19. 19.
    White V, Boyko WJ: Chronic Lymphotic Leukemia With IgM and IgG Cytoplasmic Inclusions. Arch Pathol Lab Med 107: 580–582, 1983.PubMedGoogle Scholar
  20. 20.
    Wotherspoon AC, Norton AJ, Isaacson PG: Immunoreactive cytokeratins in plasmacytomas Histopathology 14: 141–150, 1989.PubMedCrossRefGoogle Scholar
  21. 21.
    Zandecki M, Bernardi F, Lai JL: Image Analysis in Multiple Myeloma at Diagnosis. Cancer Genet Cytogenet 74: 115–119, 1994.PubMedCrossRefGoogle Scholar

Copyright information

© W B. Saunders & Company Ltd 1998

Authors and Affiliations

  • Zoltán TÓth
    • 1
  • József Sipos
    • 1
  1. 1.Department of PathologyCounty Hospital of ZalaZalaegerszegHungary

Personalised recommendations