T cell independent induction of antigen specific suppression of the antibody response

  • Luciano Adorini
  • Diana Boraschi
  • Gino Doria
Original Contributions


Immune spleen cells (from mice given 2×107 HRBC 14 days earlier) when mixedin vitro with carrier-primed syngeneic spleen cells (from mice given 2×105 HRBC 3 days earlier) are able to suppress the anti-TNP and anti-HRBC PFC response to TNP-HRBC. If immune thymocytes are substituted for spleen cells suppression is not observed. This suppression is antigen specific, resistant to anti-T treatment or x-irradiation, and is exerted by nylon wool-retained cells of the immune spleen cell population. An antigen specific suppressive factor is released from immune spleen cells in culture. Under these experimental conditions, suppression appears to be mediated by a specific product of B rather than T cells present in the immune spleen cell population.


Antibody response Immune spleen cells Immune system Immunosuppression T cells 

Abbreviation used


rabbit anti-rat brain serum


guinea pig complement


fetal calf serum


norse red blood cells


plaque-forming cells


sheep red blood cells




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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Luciano Adorini
    • 1
  • Diana Boraschi
    • 1
  • Gino Doria
    • 1
  1. 1.Centro di Studi Nucleari della Casaccia Laboratorio di RadiopatologiaGruppo CNEN-Euratom di ImmunogeneticaRomaItalia

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