Chinese Science Bulletin

, Volume 46, Issue 23, pp 1980–1984 | Cite as

Expression ofBcl-2 in cells with different telomerase activities

  • Jing Chen
  • Jianguo Ren
  • Jianyu Zheng
  • Guoping Cai
  • Yaoren Dai


Both telomerase andBcl-2 are important genes in controlling apoptosis. The activation of telomerase and the abnormal regulation ofBcl-2 are also closely related to carcinogenesis. However, little is known about the linkage between telomerase andBcl-2. The effect of activated telomerase on the expression ofBcl-2 has been investigated. It is demonstrated that in tumor and transformed cells with higher telomerase activity,Bcl-2 expression is significantly lower than that in telomerase negative or less telomerose activity cells. Further study showed that in the telomerase gene-transformed 2BS-fibroblasts,Bcl-2 expression is inhibited significantly while the exogenous telomerase catalytic subunit gene is re-expressed in fibroblasts. Results indicated that there might be a certain linkage between the expression of telomerase andBcl-2, and overexpression of exogenous telomerase gene might down regulate the expression ofBcl-2.


telomere telomerase Bcl-2


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Copyright information

© Science in China Press 2001

Authors and Affiliations

  • Jing Chen
    • 1
    • 2
  • Jianguo Ren
    • 1
  • Jianyu Zheng
    • 2
  • Guoping Cai
    • 1
  • Yaoren Dai
    • 1
  1. 1.Department of Biological Sciences and BiotechnologyTsinghua University, National Key Laboratory of Biomembrance and Membrance BiotechnologyBeijingChina
  2. 2.Institute for Molecular BiologyNankai UniversityTianjinChina

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