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Expression ofBcl-2 in cells with different telomerase activities

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Chinese Science Bulletin

Abstract

Both telomerase andBcl-2 are important genes in controlling apoptosis. The activation of telomerase and the abnormal regulation ofBcl-2 are also closely related to carcinogenesis. However, little is known about the linkage between telomerase andBcl-2. The effect of activated telomerase on the expression ofBcl-2 has been investigated. It is demonstrated that in tumor and transformed cells with higher telomerase activity,Bcl-2 expression is significantly lower than that in telomerase negative or less telomerose activity cells. Further study showed that in the telomerase gene-transformed 2BS-fibroblasts,Bcl-2 expression is inhibited significantly while the exogenous telomerase catalytic subunit gene is re-expressed in fibroblasts. Results indicated that there might be a certain linkage between the expression of telomerase andBcl-2, and overexpression of exogenous telomerase gene might down regulate the expression ofBcl-2.

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Authors and Affiliations

  1. Department of Biological Sciences and Biotechnology, Tsinghua University, National Key Laboratory of Biomembrance and Membrance Biotechnology, 100084, Beijing, China

    Jing Chen, Jianguo Ren, Guoping Cai & Yaoren Dai

  2. Institute for Molecular Biology, Nankai University, 300071, Tianjin, China

    Jing Chen & Jianyu Zheng

Authors
  1. Jing Chen
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  2. Jianguo Ren
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  3. Jianyu Zheng
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  4. Guoping Cai
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  5. Yaoren Dai
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Correspondence to Guoping Cai.

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They contributed equally to this work.

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Chen, J., Ren, J., Zheng, J. et al. Expression ofBcl-2 in cells with different telomerase activities. Chin.Sci.Bull. 46, 1980–1984 (2001). https://doi.org/10.1007/BF02901911

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  • DOI: https://doi.org/10.1007/BF02901911

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