Cryptogenic chronic active liver disease. Evaluation of serum aminoterminal peptide of type III procollagen as a marker of histological activity

  • Giulio Diodati
  • Paola Bonetti
  • Mario Plebani
  • Alda Giacomini
  • Massimo Rugge
  • Giuseppe Realdi
  • Angelo Burlina
Original Contributions


Sera from 64 patients with HBsAg-negative chronic liver disease with or without cirrhosis were investigated for aminoterminal peptide of type III procollagen (sP-III-P) as a suitable marker of hepatic fibrosis; 244 healthy control subjects were included in the study. A close correlation (p<0.01) between sP-III-P levels and histological activity was observed; on the contrary, no correlation was found between the same serum marker of liver fibroplasia and biochemical activity or clinical severity of the disease. We conclude that sP-III-P as a suitable marker of liver overload of collagen fibers is strongly correlated with the histological activity of the disease. Local immune reactions produce soluble substances that might stimulate fibroblastic activity. The test has a significant sensitivity and a very high specificity as a marker of chronic liver disease with histological activity.


CALD procollagen Fibroplasia Histological activity 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Giulio Diodati
    • 1
  • Paola Bonetti
    • 1
  • Mario Plebani
    • 2
  • Alda Giacomini
    • 2
  • Massimo Rugge
    • 4
  • Giuseppe Realdi
    • 3
  • Angelo Burlina
    • 2
  1. 1.Istituto di Medicina Clinica, Clinica Medica IIUniversità degli Studi di PadovaItalia
  2. 2.Cattedra di Biochimica ClinicaUniversità degli Studi di PadovaItalia
  3. 3.Clinica MedicaUniversità degli Studi di SassariItalia
  4. 4.Dipartimento di Patologia ClinicaUniversità degli Studi di PadovaItalia

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