Cellular aspects of rabbit masugi nephritis
Cellular events in the glomerulus in rabbit Masugi nephritis were studied. After a latent period, severe proliferative glomerulonephritis occurred by the single injection of a small amount of anti-rabbit kidney duck γ globulin. The change was well recovered within 27 days.
It was revealed that some proliferation and swelling of endothelial cells and mesangial cells could occur. However, they were not predominant cell types in the active proliferative stage. In contrast, it was confirmed that the glomerular hypercellularity was mainly caused by prominent accumulation of monocytes. Their role was supposed to be concerned with the removal of various products formed from the glomerular injuries. The monocytes exhibited a variety of transformation, including macrophages, epithelioid cells, and multinucleated giant cells. Detailed ultrastructural features of these monocytic cells were described, and compared to those of the glomerular cells.
KeywordsMesangial Cell Glomerular Basement Membrane Multinucleated Giant Cell Glomerular Cell Predominant Cell Type
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