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Virchows Archiv B

, 62:207 | Cite as

The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney

  • Walter Zumkeller
  • Paul N. Schofield
Review

Summary

Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure).

This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.

Key words

Insulin-like growth factors IGF-binding proteins IGF-receptors Renal physiology Renal pathology 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Walter Zumkeller
    • 1
    • 2
  • Paul N. Schofield
    • 2
  1. 1.Institute of Child HealthUniversity of LondonLondonUK
  2. 2.Department of AnatomyUniversity of CambridgeCambridgeUK

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