Epithelial differentiation in gliomas, meningiomas and choroid plexus papillomas
- 26 Downloads
The immunohistological findings using antibodies to different intermediate filaments (glial fibrillary acidic protein, vimentin and two types of cytokeratin) and epithelial membrane antigen are described in 89 gliomas, 19 meningiomas and 8 choroid plexus papillomas (CPPs) from adult patients. All the patients had total or subtotal surgical excision of their tumours with clinical follow up for between 3 and 7 years. The immunohistological results were correlated with the histological features and patient survival. Tumours other than low grade astrocytomas, oligodendrogliomas and anaplastic ependymomas expressed one or more epithelial markers. This immunohistological evidence of epithelial differentiation in the absence of histological epithelial features in gliomas confirms that the two are not necessarily correlated. It is concluded that the expression of epithelial markers in some intradural tumours may reflect aberrant differentiation related to the degree of anaplasia in poorly differentiated astrocytomas and glioblastomas. All the patients with anaplastic epithelial marker-positive gliomas died within 1 year, whereas only 68% of patients with marker-negative tumours died within the follow-up period. In ependymomas and meningiomas, the expression of epithelial markers may reflect their histogenesis, while in malignant CPPs such expression could denote either their aberrant differentiation or histogenetic derivation.
Key wordsBrain tumour Cytokeratin Epithelial membrane antigen Glial fibrillary acidic protein
Unable to display preview. Download preview PDF.
- Bignami A, Raju T, Dahl D (1982) Localization of vimentin, the non specific intermediate filament protein, in embryonal glia and in early differentiating neurons. In vivo and in vitro immunofluorescence study of the rat embryo with vimentin and neurofilament antisera. Dev Biol 91:286–295PubMedCrossRefGoogle Scholar
- Cosgrove MM, Rich KA, Martin SE (1988) Keratin intermediate filament expression in neoplastic and non neoplastic astrocytes. Lab Invest 60:20AGoogle Scholar
- Cruz-Sanchez FF, Rossi ML, Hughes JT (1988b) An immunohistological study of the cytogenesis and differentiation of ependymomas. Neuropathol Appl Neurobiol 14:250–251Google Scholar
- Duffy PE, Graf L, Huang Y-Y, Rapport MM (1979) Glial fibrillary acidic protein in ependymomas and other brain tumours. J Neurol Sci 401:33–146Google Scholar
- Kepes JJ (1982) Meningiomas, biology, pathology and differential diagnosis. In: Steinberg SS (ed) Masson monographs in diagnostic pathology. Masson, New York, p 3Google Scholar
- Kepes JJ, Fulling KH, Garcia JH (1982) The clinical significance of “adenoid” formations of neoplastic astrocytes, imitating metastatic carcinomas, in gliosarcomas. A review of five cases. Clin Neuropathol 4:139–150Google Scholar
- Ramon y Cajal S (1972) Histologie del System Nerveux de l’homme et des vertebres, vol 1; 2da reinpression. Consejo Superior de Investigaciones Cientificas, Madrid, pp 256Google Scholar
- Sternberger LA (1979) The unlabelled antibody peroxidase antiperoxidase (PAP) method. In: Immunohistochemistry. Wiley, Chichester, pp 297–321Google Scholar