Virchows Archiv B

, Volume 29, Issue 1, pp 65–72 | Cite as

Cytogenetic patterns in acute nonlymphocytic leukemia

  • Joseph R. Testa
  • Janet D. Rowley


Analysis of chromosomal banding patterns in acute nonlymphocytic leukemia (ANLL) reveals that approximately 50% of patients have an abnormal karyotype. Although there is substantial variability, certain nonrandom abnormalities occur, e.g., +8, −7, and the 8;21 translocation (often accompanied by loss of an X or Y chromosome). The 15;17 translocation appears to be highly specific for acute promyelocytic leukemia. These abnormalities usually are not seen in remission, but reappear in relapse, sometimes exhibiting further clonal evolution; a +8 is the most frequently observed evolutionary change. Patients with ANLL following treatment of a malignant lymphoma tend to have hypodiploid modal numbers and frequently show loss of a chromosome No. 5 or No. 7.

Key words

Acute nonlymphocytic leukemia Chromosome abnormalities Bone marrow cells Nonrandom changes 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Joseph R. Testa
    • 1
    • 2
  • Janet D. Rowley
    • 1
    • 2
  1. 1.Department of MedicineThe University of ChicagoChicagoUSA
  2. 2.The Franklin McLean Memorial Research InstituteChicagoUSA

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