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Amplifiedbcl-2/JH rearrangements in reactive lymphadenopathy

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Virchows Archiv B

Summary

Using the polymerase chain reaction (PCR) to examine the occurrence ofbcl-2/JH joining produced by t(14;18) chromosomal translocation, amplified DNA was detected in 2 of 18 lymph nodes showing reactive lymphadenopathy. The PCR was repeated in these two lymphs nodes using the same DNA samples, but no amplification was detected at the second attempt. Thus the amplified DNA was considered to be derived from one copy of joinedbcl-2/JH in one cell, or from a few copies in a few clonal cells with the same joinedbcl-2/JH. These results suggest that false joining ofbcl-2/JH at the t(14;l8) junction may occur in reactive lymph nodes.

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Authors and Affiliations

  1. First Department of Pathology, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan

    Koichi Ohshima, Masahiro Kikuchi, Shinichi Kobari, Yuichi Masuda & Fuyuki Eguchi

  2. First Department of Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan

    Nobuhiro Kimura

Authors
  1. Koichi Ohshima
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  2. Masahiro Kikuchi
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  3. Shinichi Kobari
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  4. Yuichi Masuda
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  5. Fuyuki Eguchi
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  6. Nobuhiro Kimura
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Ohshima, K., Kikuchi, M., Kobari, S. et al. Amplifiedbcl-2/JH rearrangements in reactive lymphadenopathy. Virchows Archiv B Cell Pathol 63, 197–198 (1993). https://doi.org/10.1007/BF02899261

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  • DOI: https://doi.org/10.1007/BF02899261

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