Chinese Science Bulletin

, Volume 45, Issue 16, pp 1476–1480 | Cite as

Enthalpy-entropy compensation in protein unfolding

  • Lei Liu
  • Chao Yang
  • Qingxiang Guo


Enthalpy-entropy compensation was found to be a universal law in protein unfolding based on over 3000 experimental data. Water molecular reorganization accompanying the protein unfolding was suggested as the origin of the enthalpy-entropy compensation in protein unfolding. It is indicated that the enthalpy-entropy compensation constitutes the physical foundation that satisfies the biological need of the small free energy changes in protein unfolding, without the sacrifice of the bio-diversity of proteins. The enthalpy-entropy compensation theory proposed herein also provides valuable insights into the Privalov’s puzzle of enthalpy and entropy convergence in protein unfolding.


enthalpy-entropy compensation protein unfolding water molecular reorganization 


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Copyright information

© Science in China Press 2000

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of Science and Technology of ChinaHefeiChina

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