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Low fasting serum insulin in Japanese alcohol consumers does not imply improved coronary risk factors

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objective

The effects of alcohol consumption on coronary risk factors (CRFs) and insulin resistance (IR) have seemed equivocal in previous studies. This study aimed to clarify the implications of low fasting blood insulin observed in alcohol consumers as related to CRFs and IR.

Methods

A cross-sectional observation in 2133 middle-aged healthy Japanese men for associations of increases in alcohol consumption, fasting serum insulin concentration and serum gammaglutamyltransferase (GGT) activity with the major CRFs of high systolic blood pressure (SBP), fasting serum glucose, triglycerides (TG), total- and LDL-cholesterol (tCh&LDLc) and low serum HDL-cholesterol (HDLc).

Results

Increased alcohol consumption was related to higher SBP, serum GGT, glucose and HDLc, and lower serum LDLc and insulin. Although high serum insulin was significantly related to all of the CRFs in all nondrinkers, moderate drinkers consuming up to 59 ml of alcohol per day and excessive drinkers consuming more, the means of SBP, serum glucose and HDLc were significantly higher and serum LDLc was lower in drinkers than in nondrinkers at any level of serum insulin, indicating that the good and bad profiles of CRFs in alcohol consumers are independent of their low fasting serum insulin. High serum GGT related to increased alcohol consumption and/or body weight was significantly associated with high serum insulin and all of the CRFs in all categories of alcohol consumption.

Conclusions

Low fasting serum insulin observed in drinkers does not imply improved CRFs, and thus may not imply improved IR. High serum GGT may reflect increased IR in both drinkers and nondrinkers.

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References

  1. Colditz GA, Branch LG, Lipnick RJ, et al. Moderate alcohol and decreased cardiovascular mortality in an elderly cohort. Am Heart J. 1985;109:886–889.

    Article  PubMed  CAS  Google Scholar 

  2. Dyer AR, Stamler J, Paul O, et al. Alcohol consumption and 17-year mortality in the Chicago Western Electronic Company Study. Prev Med. 1980;9:78–90.

    Article  PubMed  CAS  Google Scholar 

  3. Marmot MG, Rose G, Shipley MJ, Thomas BJ. Alcohol and mortality: A U-shaped curve. Lancet. 1981;1:580–583.

    Article  PubMed  CAS  Google Scholar 

  4. Nakanishi N, Suzuki K, Tatara K. Alcohol consumption and risk for development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men. Diabetes Care. 2003; 26:48–54.

    Article  PubMed  Google Scholar 

  5. Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG, Prospective study of risk factors for development of non-insulin dependent diabetes in middleaged British men. Brit J Med. 1995;310:560–564.

    CAS  Google Scholar 

  6. Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. Brit J Med. 1995;310:555–559.

    CAS  Google Scholar 

  7. Tsumura K, Endo G, Hayashi T, Fujii S, Suematsu C, Okada K. Daily alcohol consumption and the risk of type 2 diabetes in Japanese men. The Osaka Study. Diabetes Care. 1999;22: 1432–1437.

    Article  CAS  Google Scholar 

  8. Wei M, Kampert JB, Gibbons LW, Blair SN, Mitchell TL. Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care. 2000;23:18–22.

    Article  PubMed  CAS  Google Scholar 

  9. Dixon JB, Dixon ME, O’Brien PE. Alcohol consumption in the severely obese: relationship with the metabolic syndrome. Obes Res. 2002;10:245–252.

    Article  PubMed  Google Scholar 

  10. Rosell M, De Faire U, Hellenius ML. Low prevalence of the metabolic syndrome in wine drinkers—is it the alcohol beverage or the lifestyle? Eur J Clin Nutr. 2003;57:227–234.

    Article  PubMed  CAS  Google Scholar 

  11. Lee DH, Ha MH, Kim JR, GrossM, Jacobs DR. Gammaglutamyltransferase, alcohol, and blood pressure: a four year follow-up study. Ann Epidemiol. 2002;12:90–96.

    Article  PubMed  Google Scholar 

  12. Miura K, Nakagawa H, Nakamura H, et al.. Serum gammaglutamyl transferase level in predicting hypertension among male drinkers. J Hum Hypertens. 1994;8:445–459.

    PubMed  CAS  Google Scholar 

  13. Yamada Y, Ishizaki M, Kido T, et al. Alchol, high blood pressure, and serum γ-glutamyl transpeptidase level. Hypertension. 1991;18:819–826.

    PubMed  CAS  Google Scholar 

  14. Lee DH, Ha MH, Kim JH, et al. Gamma-glutamyltransferase and diabetes—a 4 year follow-up study. Diabetol. 2003;46:359–364.

    Article  CAS  Google Scholar 

  15. Nakanishi N, Nishina K, Li W Sato M, Suzuki K, Tatara K. Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men. J Intern Med. 2003;254:287–295.

    Article  PubMed  CAS  Google Scholar 

  16. Perry IJ, Wannamethee SG, Shaper AG. Prospective study of serum γ-glutamyltransferase and risk of NIDDM. Diabetes Care. 1998;21:732–237.

    Article  PubMed  CAS  Google Scholar 

  17. Hashimoto Y, Futamura A, Nakarai H, Nakahara K. Relationship between response of γ-glutamyl transpeptidase to alcohol drinking and risk factors for coronary heart disease. Atherosclerosis. 2001;158:465–470.

    Article  PubMed  CAS  Google Scholar 

  18. Rantala AO, Lilja M, Kauma H, Savolainen MJ, Reunanen A, Kesaniemi YA. Gamma-glutamyl transpeptidase and the metabolic syndrome. J Intern Med. 2000;248:230–238.

    Article  PubMed  CAS  Google Scholar 

  19. Yamada Y, Noborisaka Y, Suzuki H, Ishizaki M, Yamada S. Alcohol consumption, serum gamma-glutamyltransferase levels, and coronary risk factors in a middle-aged occupational population. J Occup Health. 2003;45:293–299.

    Article  PubMed  CAS  Google Scholar 

  20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetol. 1985;28:412–419.

    Article  CAS  Google Scholar 

  21. Kiechl S, Willeit J, Poewe W, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). Brit Med J. 1996; 313:1040–1041.

    PubMed  CAS  Google Scholar 

  22. Lazarus R, Sparrow D, Weiss ST. Alcohol intake and insulin levels. The Normative Aging Study. Am J Epidemiol. 1997; 145:909–916.

    PubMed  CAS  Google Scholar 

  23. Mayer EJ, Newman B, Quesenberry CP, Friedman G, Selby JV. Alcohol consumption and insulin concentrations. Role of insulin in association of alcohol intake with high-density lipoprotein cholesterol and triglycerides. Circulation 1993; 88[part 1]:2190–2197.

    PubMed  CAS  Google Scholar 

  24. Razzay G, Heaton KW. Moderate alcohol consumption has been shown previously to improve insulin sensitivity in men. Brit J Med. 1997;314:443–444.

    Google Scholar 

  25. Yamada Y Noborisaka Y, Ishizaki M, Tsuritani I, Honda R, Yamada S. Alcohol consumption, homeostasis model assessment indices and blood pressure in middle-aged healthy men. J Hum Hypertens. 2004;18:343–350.

    Article  PubMed  CAS  Google Scholar 

  26. Friedewald WT. Estimation of the concentration of lowdensity lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem. 1972;18:499–509.

    PubMed  CAS  Google Scholar 

  27. Cubeddu LX, Hoffman IS. Insulin resistance and uppernormal glucose levels in hypertension: a review. J Hum Hypertens 2002;16(Suppl 1):S52-S55.

    Article  PubMed  CAS  Google Scholar 

  28. Lu W, Jablonski KA, Resnick HE, et al. Alcohol intake and glycemia in American Indians: The Strong Heart Study. Metabolism. 2003;52:129–135.

    Article  PubMed  CAS  Google Scholar 

  29. Dorn JM Hovey K, Muti P, et al. Alcohol drinking patterns differentially affect central adiposity as measured by abdominal height in women and men. J Nutr. 2003;133:2655–2662.

    PubMed  CAS  Google Scholar 

  30. Mayes PA. Gluconeogenesis and control of the blood glucose. In: Murray RK, Granner DK, Mayes PA, Rodwell VW eds. Harper’s Biochemistry 25th ed. New York: McGraw-Hill, 2000;208–218.

    Google Scholar 

  31. den Boer M, Voshol PJ, Kuipers F, Havekes LM, Romjin JA. Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models. Artherioscler Thromb Vasc Biol. 2004;24:644–649.

    Article  CAS  Google Scholar 

  32. Saglam K, Kilic R, Yilmaz MI, Gulee M, Baykal Y, Kutlu M. Insulin resistance in patients with steatohepatitis. Hepatogastroenterology. 2003;50:456–459.

    PubMed  Google Scholar 

  33. Arima H, Kiyohara Y, Kato I, et al. Alcohol reduces insulinhypertension relationship in a general population. The Hisayama study. J Clin Epidemiol. 2002;55:863–869.

    Article  PubMed  Google Scholar 

  34. Bell DSH. Alcohol and the NIDDM patient. Diabetes Care. 1996;19:509–513.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University, 1-1 Daigaku, 920-0293, Uchinada, Ishikawa, Japan

    Yuichi Yamada, Yuka Noborisaka, Masao Ishizaki, Ikiko Tsuritani & Ryumon Honda

Authors
  1. Yuichi Yamada
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  2. Yuka Noborisaka
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  3. Masao Ishizaki
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  4. Ikiko Tsuritani
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  5. Ryumon Honda
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Correspondence to Yuichi Yamada.

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Yamada, Y., Noborisaka, Y., Ishizaki, M. et al. Low fasting serum insulin in Japanese alcohol consumers does not imply improved coronary risk factors. Environ Health Prev Med 9, 243–250 (2004). https://doi.org/10.1007/BF02898137

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  • DOI: https://doi.org/10.1007/BF02898137

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