Journal of Tongji Medical University

, Volume 14, Issue 4, pp 213–215 | Cite as

Phenotype analysis of mononuclear cells in endomyocardial biopsy specimens from patients with viral myocarditis and dilated cardiomyopathy

  • Li Wu
  • Yu Shu
  • Wang Dao-wen


This study investigated the distribution and phenotype of mononuclear cells in endomyocardial biopsy (EMB) specimens from patients with viral myocarditis (VMC, 25 cases) and dilated cardiomyopathy (DCM, 10 cases). T lymphocytes, including Th/i cells in VMC and Tc/s cells in DCM, predominated in the infiltrating mononuclear cells in these specimens. The morphological relationship between infiltration of T lymphocytes and pathological changes of myocardia was also observed and neither macrophages nor B lymphocytes were found.

Key words

myocarditis congestive cardiomyopathy biopsy, myocardium T lymphocyte 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kereiakes D J, Parmley W W. Myocarditis and cardiomyopathy. Am Heart J, 1984; 108: 1319Google Scholar
  2. 2.
    Deguchi H, Hayashi T, Kotaka Met al. In situ analysis with monoclonal antibodies of lymphocyte subsets in myocardial biopsies from patients with dilated cardiomyopathy and idiopathic (viral) myocarditis. Jpn Circ J, 1987; 51: 1365PubMedGoogle Scholar
  3. 3.
    1987, 26: 597.Google Scholar
  4. 4.
    WHO/ISFC Task Force. Report of the WHO/ ISFC task force on the definition and classification. of cardiomyopathies. Br Heart J, 1980; 44: 672CrossRefGoogle Scholar
  5. 5.
    Aretz H T, Billingham M E, Edwards W Det al. Myocarditis; a histopathologic definition and classification. Am J Cardiovasc Pathol, 1987, 1: 3PubMedGoogle Scholar
  6. 6.
    1986, 15: 282Google Scholar
  7. 7.
    1990. 69–70Google Scholar
  8. 8.
    1990, 7, 10Google Scholar
  9. 9.
    1991: 89–92Google Scholar
  10. 10.
    1989, 18: 79Google Scholar

Copyright information

© Springer 1994

Authors and Affiliations

  • Li Wu
    • 1
  • Yu Shu
    • 1
  • Wang Dao-wen
    • 1
  1. 1.Department of Internal Medicine, Tongji HospitalTongji Medical UniversityWuhan

Personalised recommendations