A symmetry-related sequence-structure relation of proteins
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Proteins have regular tertiary structures but irregular amino acid sequences. This made it very difficult to decode the structural information in the protein sequences. Here we demonstrate that many small α protein domains have hidden sequence symmetries characteristic of their pseudo-symmetric tertiary structures. We also present a modified method of recurrent plot to reveal this kind of the hidden sequence symmetry. The results may enable us to understand part of the relations between protein sequences and their tertiary structures.
Keywordsprotein symmetry sequence-structure relation recurrence quantification analysis
- 11.Mount, D. W., Bioinformatics: Sequences and Genome Analysis, New York: Cold Spring Harbor Laboratory Press, 2001, 428.Google Scholar