Chinese Science Bulletin

, 50:536 | Cite as

A symmetry-related sequence-structure relation of proteins

  • Ruizhen Xu
  • Mingfen Li
  • Hanlin Chen
  • Yanzhao Huang
  • Yi Xiao


Proteins have regular tertiary structures but irregular amino acid sequences. This made it very difficult to decode the structural information in the protein sequences. Here we demonstrate that many small α protein domains have hidden sequence symmetries characteristic of their pseudo-symmetric tertiary structures. We also present a modified method of recurrent plot to reveal this kind of the hidden sequence symmetry. The results may enable us to understand part of the relations between protein sequences and their tertiary structures.


protein symmetry sequence-structure relation recurrence quantification analysis 


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Copyright information

© Science in China Press 2005

Authors and Affiliations

  • Ruizhen Xu
    • 1
  • Mingfen Li
    • 1
  • Hanlin Chen
    • 1
  • Yanzhao Huang
    • 1
  • Yi Xiao
    • 1
  1. 1.Biomolecular Physics and Modeling Group, Department of PhysicsHuazhong University of Science and TechnologyWuhanChina

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