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Cancer Chemotherapy and Pharmacology

, Volume 26, Issue 3, pp 239–240 | Cite as

A pilot study of metoclopramide, dexamethasone, diphenhydramine and acupuncture in women treated with cisplatin

  • L. Aglietti
  • F. Roila
  • M. Tonato
  • C. Basurto
  • S. Bracarda
  • M. Picciafuoco
  • E. Ballatori
  • A. Del Favero
Short Communication

Summary

A total of 26 women who submitted to cisplatin chemotherapy received as antiemetic treatment a combination of metoclopramide, dexamethasone and diphenhydramine. Acupuncture according to traditional Chinese medicine was also carried out. The results were compared with those obtained in a similar group of women with cancer, who were treated in the same setting with the same antiemetic combination but without additional acupuncture. Acupuncture was shown to increase complete protection from nausea and to decrease the intensity and duration of nausea and vomiting. However, the difficulties of performing acupuncture routinely in daily practice are a hindrance to its wider use.

Keywords

Traditional Chinese Medicine CDDP Metoclopramide Diphenhydramine Complete Protection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Dundee JW, Ghaly RG, Fitzpatrick KTJ, Lynch GA, Abram WP (1987) Acupuncture to prevent cisplatin-associated vomiting. Lancet I: 1083CrossRefGoogle Scholar
  2. 2.
    Roila F, Tonato M, Basurto C, Bella M, Passalacqua R, Morsia D, Di Costanzo F, Donati D, Ballatori E, Tognoni G, Franzosi MG, Del Favero A (1987) Antiemetic activity of high doses of metoclopramide combined with methylprednisolone versus metoclopramide alone in cisplatin-treated cancer patients: a randomized double-blind trial of the Italian Oncology Group for Clinical Research. J Clin Oncol 5: 141–149PubMedGoogle Scholar
  3. 3.
    Roila F, Tonato M, Basurto C, Picciafuoco M, Bracarda S, Donati D, Malacarne P, Monici L, Di Costanzo F, Patoia L, Ballatori E, Tognoni G, Del Favero A (1989) Protection from nausea and vomiting in cisplatin-treated patients: high-dose metoclopramide combined with methylprednisolone versus metoclopramide combined with dexamethasone and diphenhydramine: A study of the Italian Oncology Group for Clinical Research. J Clin Oncol 7: 1693–1700PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. Aglietti
    • 1
  • F. Roila
    • 1
  • M. Tonato
    • 1
  • C. Basurto
    • 1
  • S. Bracarda
    • 1
  • M. Picciafuoco
    • 1
  • E. Ballatori
    • 2
  • A. Del Favero
    • 3
  1. 1.Medical Oncology DivisionOspedale PoliclinicoPerugia
  2. 2.Department of Statistical SciencesUniversity of PerugiaPerugia
  3. 3.Institute of Internal Medicine IUniversity of PerugiaPerugiaItaly

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