Serum IL-10 level in allergic rhinitis patients and its effect on serum total IgE
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To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142.6±28.2 KUΛ/L. In the normal control group, they were 12.86±2.88 pg/mL and 47.2±12.2 KUΛ. There were significant differences between the two groups (P<0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r=−0.46,P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.
Key wordsallergic rhinitis IL-10 total IgE
- 2.WU Y J, CHEN R H. IL-10 downregulates expression of cyclo-oxygenase-2 and its mediated PGE2 production on human mesangial cells. Immunol J, 2001, 17: 421.Google Scholar
- 3.Otorhinolaryngology Branch of China Medical Association. Diagnosis Criterion of Allergic Rhinitis (revised, Haikou, 1997). Chin J Otorhinolaryngol, 1998, 33: 134Google Scholar