Summary
To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142.6±28.2 KUΛ/L. In the normal control group, they were 12.86±2.88 pg/mL and 47.2±12.2 KUΛ. There were significant differences between the two groups (P<0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r=−0.46,P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Levings M K. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol, 2002, 129: 263.
WU Y J, CHEN R H. IL-10 downregulates expression of cyclo-oxygenase-2 and its mediated PGE2 production on human mesangial cells. Immunol J, 2001, 17: 421.
Otorhinolaryngology Branch of China Medical Association. Diagnosis Criterion of Allergic Rhinitis (revised, Haikou, 1997). Chin J Otorhinolaryngol, 1998, 33: 134
Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol, 2001, 108(Suppl 5): 147
Abdelnoor A M, Kobeissy F, Farhat Det al. Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon. Clin Mol Allergy, 2004, 2(1): 6
Ngoc L P, Gold D R, Tzianabos A Oet al. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol, 2005, 5(2): 161
Fernando R, Chan R. Anti-inflammatory pre-treatment and the resultant effects of interleukin-10: adjuncts to multi-therapeutical strategies. Perfusion, 2000, 15: 501
Author information
Authors and Affiliations
Additional information
LIU Guanghui, male, born in 1952, Associate Professor
Rights and permissions
About this article
Cite this article
Guanghui, L., Rongfei, Z. Serum IL-10 level in allergic rhinitis patients and its effect on serum total IgE. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 25, 724–725 (2005). https://doi.org/10.1007/BF02896183
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02896183