Expression profile of metastasis-associated genes in esophageal squamous cell carcinoma
- 33 Downloads
The differentially expressed genes between esophageal squamous cell carcinoma (ESCC) with or without lymphatic metastasis were investigated by gene chip and the lymphatic metastasis-associated genes were screened out. Expression array was used to detect the mRNA from both the primary carcinoma and the corresponding esophageal epithelium in 15 cases of human ESCC. The lymphatic metastasis-associated genes were screened by bioinformatics between ESCC with or without lymphatic metastasis. The results showed that 43 (4.85%) genes significantly differed between the ESCC with and without lymphatic metastasis (P<0.05), of which 18 (2.03%) were upregulated and 25 (2.82%) down-regulated. The up-regulated genes were involved in cell adhesion molecules and cell membrane receptors and the down-regulated genes were mostly cell cycle regulators and intracellular signaling molecules. It was suggested that lymphatic metastasis-associated genes were screened by gene chip, which was helpful to understand the molecular mechanism of ESCC lymphatic metastasis and lymphatic metastasis-associated genes might be used as diagnostic markers and therapeutic targets for lymphatic metastasis.
Key wordsesophageal squamous cell carcinoma gene chip lymphatic metastasis gene expression profile
Unable to display preview. Download preview PDF.
- 7.Xu L, Chen S, Bergan R C, MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer. Oncogene, 2006 Jan 16, [Epub ahead of print]Google Scholar
- 10.Wan Y. Gene expression-driven diagnostics and pharmacogenomics in cancer. Curr Opin Mol Ther, 2005, 7 (3):246–250Google Scholar