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Epinephrine and cortisol responses to work: A test of the models of Frankenhaeuser and Karasek

  • Empirical Research
  • Published:
Annals of Behavioral Medicine

Abstract

Both Frankenhaeuser and Karasek have put forward models describing how job demand and control influence epinephrine and cortisol levels. These models were tested in a sample of 53 women and 51 men in a variety of occupations. They were studied over one rest day and two working days. Subjects reported their perceived demand and control and their mood on each day, as well as providing urine for assessment of urinary excretion rates of epinephrine and cortisol. In men, but not women, epinephrine levels were higher on the working days than on the rest day, and demand was found to covary positively with epinephrine, supporting Frankenhaeuser's model with respect to epinephrine variation in men. However, cortisol levels were not elevated on working days compared to the rest day, and no relationship between job control and cortisol was seen which is in contradiction of Frankenhaeuser's model with respect to cortisol variation. There was some suggestion that demand was most strongly associated with elevated epinephrine in men when job control was low in accordance with Karasek's model, but there was no evidence for such an effect with respect to cortisol.

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References

  1. House J, McMichael A, Wells J, Kaplan B, Landerman L: Occupational stress and health among factory workers.Journal of Health and Social Behavior. 1979,20:139–160.

    Article  PubMed  CAS  Google Scholar 

  2. Johnson J, Hall E: Job strain, work place social support, and cardiovascular disease: A cross-sectional study of a random sample of the Swedish working population.American Journal of Public Health. 1988,78:1336–1342.

    PubMed  CAS  Google Scholar 

  3. Pieper C, LaCroix A, Karasek RA: The relation of psychosocial dimensions of work with coronary heart disease risk factors: A meta-analysis of five United States data bases.American Journal of Epidemiology. 1989,129:483–494.

    PubMed  CAS  Google Scholar 

  4. Sauter S, Hurrell J, Cooper C (eds):Job Control and Worker Health. Chichester, England: Wiley, 1989.

    Google Scholar 

  5. Karasek RA, Theorell T:Healthy Work: Stress, Productivity, and the Reconstruction of Working Life. New York: Basic Books, 1990.

    Google Scholar 

  6. Frankenhaeuser M, Lundberg U, Fredrikson M, et al: Stress on and off the job as related to sex and occupational status in white-collar workers.Journal of Organizational Behavior. 1989,10: 321–346.

    Article  Google Scholar 

  7. Krantz DS, Contrada RJ, Hill DR, Friedler E: Environmental stress and biobehavioral antecedents of coronary heart disease.Journal of Consulting and Clinical Psychology. 1988,56:333–341.

    Article  PubMed  CAS  Google Scholar 

  8. Frankenhaeuser M, Lundberg U, Forsman L: Dissociation between sympathetic-adrenal and pituitary-adrenal responses to an achievement situation characterized by high controllability: Comparison between Type A and Type B males and females.Biological Psychology. 1980,10:79–91.

    Article  PubMed  CAS  Google Scholar 

  9. Lundberg U: Catecholamine and cortisol excretion under psychologically different laboratory conditions. In Usdin E, Kvetnansky R, Kopin I (eds),Catecholamines and Stress: Recent Advances. Amsterdam, Netherlands: Elsevier, 1980, 455–476.

    Google Scholar 

  10. Lundberg U, Frankenhaeuser M: Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort.Journal of Psychosomatic Research. 1980,24:125–130.

    Article  PubMed  CAS  Google Scholar 

  11. Frankenhaeuser M: A biopsychosocial approach to work life issues.International Journal of Health Services. 1989,19:747–758.

    Article  PubMed  CAS  Google Scholar 

  12. Frankenhaeuser M: The psychophysiology of workload, stress, and health: Comparison between the sexes.Annals of Behavioral Medicine. 1991,13:197–204.

    Google Scholar 

  13. Frankenhaeuser M, Rauste von Wright M, Collins A, et al: Sex differences in psychoneuroendocrine reactions to examination stress.Psychosomatic Medicine. 1978,40:334–343.

    PubMed  CAS  Google Scholar 

  14. Stoney CM, Davis M, Matthews KA: Sex differences in physiological responses to stress and in coronary heart disease.Psychophysiology. 1987,4:127–131.

    Article  Google Scholar 

  15. Karasek RA: Job demands, job decision latitude, and mental strain: Implications for job redesign.Administrative Science Quarterly. 1979,24:285–308.

    Article  Google Scholar 

  16. Landsbergis PA: Occupational stress among health care workers: A test of the job demands-control model.Journal of Organizational Behavior. 1988,9:217–239.

    Article  Google Scholar 

  17. Perrewe P, Ganster D: The impact of job demands and behavioral control on experienced job stress.Journal of Organizational Behavior. 1989,10:213–230.

    Article  Google Scholar 

  18. Kushnir T, Melamed S: Workload, perceived vontrol, and psychological distress in Type A/B industrial workers.Journal of Organizational Behavior. 1991,12:155–168.

    Article  Google Scholar 

  19. Karasek RA: Control in the workplace and its health-related impacts. In Sauter S, Hurrell J, Cooper C (eds),Job Control and Worker Health. Chichester, England: Wiley, 1989, 129–159.

    Google Scholar 

  20. Karasek RA, Baker D, Marxer F, Ahlbom A, Theorell T: Job decision latitude, job demands, and cardiovascular disease: A prospective study of Swedish men.American Journal of Public Health. 1981,71:694–705.

    PubMed  CAS  Google Scholar 

  21. Karasek RA, Theorell T, Schwartz J, et al: Job characteristics in relation to the prevalence of myocardial infarction in the U.S. Health Examination Survey (HES) and the Health and Nutrition Examination Survey (HANES).American Journal of Public Health. 1988,78:910–918.

    PubMed  CAS  Google Scholar 

  22. Schnall PL, Landsbergis PA, Baker D: Job strain and cardiovascular disease.Annual Review of Public Health. 1994,15:381–411.

    Article  PubMed  CAS  Google Scholar 

  23. Karasek RA, Russell R, Theorell T: Physiology of stress and regeneration in job-related cardiovascular illness.Journal of Human Stress. 1982,8:29–42.

    Google Scholar 

  24. Brantley P, Dietz L, McKnight G, Tulley R: Convergence between the Daily Stress Inventory and endocrine measures of stress.Journal of Consulting and Clinical Psychology. 1988,56:549–551.

    Article  PubMed  CAS  Google Scholar 

  25. Jenner D, Reynolds V, Harrison GA: Catecholamine excretion rates and occupation.Ergonomics. 1980,23:237–246.

    Article  PubMed  CAS  Google Scholar 

  26. Harrison GA, Palmer C, Jenner D, Reynolds V: Associations between rates of urinary catecholamine excretion and aspects of lifestyle among adult women in some Oxfordshire villages.Human Biology. 1981,53:617–633.

    CAS  Google Scholar 

  27. Johansson G, Aronsson G: Stress reactions in computerized administrative work.Journal of Occupational Behavior. 1984,5: 159–181.

    Article  Google Scholar 

  28. Pollard T, Ungpakorn G, Harrison GA: Some determinants of population variation in cortisol levels in a British urban community.Journal of Biosocial Science. 1992,24:477–485.

    PubMed  CAS  Google Scholar 

  29. Johansson G, Aronsson G, Lindstrom B: Social, psychological, and neuroendocrine stress reactions in highly mechanized work.Ergonomics. 1978,21:583–599.

    Article  PubMed  CAS  Google Scholar 

  30. Timio M, Gentili S, Pede S: Free adrenaline and noradrenaline excretion related to occupational stress.British Heart Journal. 1979,42:471–474.

    Article  PubMed  CAS  Google Scholar 

  31. Fibiger W, Christensen F, Singer G, Kaufmann H: Mental and physical components of sawmill operatives' workload.Ergonomics. 1986,29:363–375.

    Article  PubMed  CAS  Google Scholar 

  32. Levi L: The stress of everyday work as reflected in productiveness, subjective feelings, and urinary output of adrenaline and noradrenaline under salaried and piecework conditions.Journal of Psychosomatic Research. 1964,8:199–202.

    Article  PubMed  CAS  Google Scholar 

  33. Rissler A: Stress reactions at work and after work during a period of quantitative overload.Ergonomics. 1977,20:577–580.

    Google Scholar 

  34. Cox S, Cox T, Thirlaway M, Mackay C: Effects of simulated repetitive work on urinary catecholamine excretion.Ergonomics. 1982,25:1129–1141.

    Article  PubMed  CAS  Google Scholar 

  35. Lundberg U, Granqvist M, Hansson T, Magnusson M, Wallin L: Psychological and physiological stress responses during repetitive work at an assembly line.Work and Stress. 1989,3:143–153.

    Article  Google Scholar 

  36. Office of Population Censuses and Surveys:Classification of Occupations and Coding Index. London: HMSO, 1980.

    Google Scholar 

  37. Warr P: Decision latitude, job demands, and employee well-being.Work and Stress. 1990,4:285–294.

    Article  Google Scholar 

  38. Cronbach L: Coefficient alpha and the internal structure of tests.Psychometrika. 1951,16:297–334.

    Article  Google Scholar 

  39. Mackay C, Cox T, Burrows G, Lazzerini T: An inventory for the measurement of self-reported stress and arousal.British Journal of Social and Clinical Psychology, 1978,17:283–284.

    PubMed  CAS  Google Scholar 

  40. King M, Burrows G, Stanley G: Measurement of stress and arousal: Validation of the stress/arousal adjective checklist.British Journal of Psychology. 1983,74:473–479.

    PubMed  Google Scholar 

  41. Cruickshank P: A stress and arousal mood scale for low vocabulary subjects: A reworking of Mackayet al. (1978).British Journal of Psychology. 1984,75:89–94.

    PubMed  Google Scholar 

  42. Warr P: The measurement of well-being and other aspects of mental health.Journal of Occupational Psychology. 1990,63:193–210.

    Google Scholar 

  43. Sevastos P, Smith L, Cordery J: Evidence on the reliability and construct validity of Warr's (1990) well-being and mental health measures.Journal of Occupational and Organizational Psychology. 1992,65:33–49.

    Google Scholar 

  44. Jenner D, Brown M, Lhoste F: Determination of alpha-methyl-dopa, alpha-methylnoradrenaline, noradrenaline, and adrenaline in plasma using high-performance liquid chromatography with UV detection.Journal of Chromatography. 1981,224:507–517.

    Article  CAS  Google Scholar 

  45. Jenner D, Richards J: Determination of cortisol and cortisone in urine using high performance liquid chromatography with UV detection.Journal of Pharmaceutical and Biomedical Analysis. 1985,3:251–257.

    Article  PubMed  CAS  Google Scholar 

  46. Fredrikson M: Psychophysiological and biochemical indices in ‘stress’ research: Applications to psychopathology and pathophysiology. In Turpin G (ed),Handbook of Clinical Psychophysiology. Chichester, England: Wiley, 1989, 241–279.

    Google Scholar 

  47. Akerstedt T, Gillberg M, Hjemdahl P, et al: Comparison of urinary and plasma catecholamine responses to mental stress.Acta Physiologica Scandinavica. 1983,117:19–26.

    Article  PubMed  CAS  Google Scholar 

  48. Pollard TM: Use of cortisol as a stress marker: Practical and theoretical problems.American Journal of Human Biology. 1995,7: 265–274.

    Article  Google Scholar 

  49. Jenner D: Population studies of variation in catecholamine and corticosteroid variation. DPhil Thesis, University of Oxford, 1985.

  50. James GD, Jenner DA, Harrison GA, Baker PT: Differences in catecholamine excretion rates, blood pressure, and lifestyle among young Western Samoan men.Human Biology. 1985,57:635–647.

    CAS  Google Scholar 

  51. Ward M, Mefford I: Methodology of studying catecholamine response to stress. In Steptoe A, Rueddel H, Neus H (eds),Clinical and Methodological Issues in Cardiovascular Psychophysiology. Berlin, Germany: Springer-Verlag, 1985, 131–143.

    Google Scholar 

  52. James GD, Crews D, Pearson J: Catecholamines and stress. In Little M, Haas J (eds),Human Population Biology. Oxford, England: Oxford University Press, 1989, 280–295.

    Google Scholar 

  53. Kirschbaum C, Hellhammer D: Salivary cortisol in psychobiological research: An overview.Neuropsychobiology. 1989,22:150–169.

    Article  PubMed  CAS  Google Scholar 

  54. Russell D: The analysis of psychophysiological data: Multivariate approaches. In Cacioppo J, Tassinary L (eds),Principles of Psychophysiology. Cambridge, England: Cambridge University Press, 1990, 775–801.

    Google Scholar 

  55. Gallucci WT, Baum A, Laue L, et al: Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis.Health Psychology. 1993,12:420–425.

    Article  PubMed  CAS  Google Scholar 

  56. van Eck M, Nicolson NA: Perceived stress and salivary cortisol in daily life.Annals of Behavioral Medicine. 1994,16:221–227.

    Google Scholar 

  57. Frankenhaeuser M, Johansson G: Stress at work: Psychobiological and psychosocial aspects.International Review of Applied Psychology. 1986,35:287–299.

    Article  Google Scholar 

  58. Baum, A, Grunberg N: Gender, stress, and health.Health Psychology. 1991,10:80–85.

    Article  PubMed  CAS  Google Scholar 

  59. Frankenhaeuser M: The psychophysiology of sex differences as related to occupational status. In Frankenhaeuser M, Lundberg U, Chesney M (eds),Women, Work and Health: Stress and Opportunities. New York: Plenum Press, 1991, 39–61.

    Google Scholar 

  60. Saab PG, Matthews KA, Stoney CM, McDonald RH: Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral stressors.Psychophysiology. 1989,26:270–280.

    Article  PubMed  CAS  Google Scholar 

  61. Spector P: Interactive effects of perceived control and job stressors on affective reactions and health outcomes for clerical workers.Work and Stress. 1987,1:155–162.

    Article  Google Scholar 

  62. Fletcher B, Jones F: A refutation of Karasek's demand-discretion model of occupational stress with a range of dependent measures.Journal of Organizational Behavior. 1993,14:319–330.

    Article  Google Scholar 

  63. Theorell T, Perski A, Akerstedt T, et al: Changes in job strain in relation to changes in physiological state.Scandinavian Journal of Work and Environmental Health. 1988,14:189–196.

    CAS  Google Scholar 

  64. Doncevic S, Theorell T, Scalia-Tomba G: The psychosocial work environment of district nurses in Sweden.Work and Stress. 1988,2:341–351.

    Article  Google Scholar 

  65. Harenstam A, Theorell T: Cortisol elevation and serum gammaglutamyl transpeptidase in response to adverse job conditions: How are they interrelated.Biological Psychology. 1990,31:157–171.

    Article  PubMed  CAS  Google Scholar 

  66. Theorell T, Ahlberg-Hulten G, Jodko M, Sigala F, de la Torre B: Influence of job strain and emotion on blood pressure in female hospital personnel during work hours.Scandinavian Journal of Work and Environmental Health. 1993,19:313–318.

    CAS  Google Scholar 

  67. Theorell T, Ahlberg-Hulten G, Sigala F, Perski A, Soderholm M: A psychosocial and biomedical comparison between men in six contrasting service occupations.Work and Stress. 1990,4:51–63.

    Article  Google Scholar 

  68. Fibiger W, Singer G, Miller A, Armstrong S, Datar M: Cortisol and catecholamine changes as functions of time-of-day and self-reported mood.Neuroscience and Biobehavioral Review. 1984,8: 523–530.

    Article  CAS  Google Scholar 

  69. Brown WA, Sirota AD, Niaura R, Engebretson TO: Endocrine correlates of sadness and elation.Psychosomatic Medicine. 1993,55:458–467.

    PubMed  CAS  Google Scholar 

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Preparation of this manuscript was supported in part by awards from the Parkes Foundation and the Ruggles-Gates Fund of the Royal Anthropological Institute.

The authors would like to thank the people of Oxford who made this study possible.

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Pollard, T.M., Ungpakorn, G., Harrison, G.A. et al. Epinephrine and cortisol responses to work: A test of the models of Frankenhaeuser and Karasek. Ann Behav Med 18, 229–237 (1996). https://doi.org/10.1007/BF02895284

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