Virchows Archiv B

, 9:153 | Cite as

Morphologische Veränderungen der Mäuse-Leber nach Inoculation von Arbo-Virus (typ Be An 67949)

  • F. Huth
  • R. de Araujo

Morphologic changes of mouse-liver after inoculation of arbo-virus (type Be An 67949)


6–8 days post inoculation of Arbo-virus of type Be An 67949 differentiated virus particles with a medium size of 90 mμ can be observed in endothelial nuclei of newborn mice liver. The virus particles are characterized by double or single capsides and a dense round or polar center. Intranuclear virus reduplication is accompanied by strong proliferation of sinus lining cells and intensive necroses of liver parenchyma. In addition large intranuclear and varying intracytoplasmatic inclusion bodies are visible. The BeAn 67949 virus particles and the virogeneous hepatitis differ from those after inoculation of other virus and other virus hepatitis. The Be An 67949 virus induced hepatitis could be regarded as a model for a human virus hepatitis.


  1. Araujo, R., Bullon, A., Jr.: Elektronenmikroskopische Befunde in der Lunge anch Arbovirus Be An 67949 bei der Maus (Referat). Zbl. allg. Path. path. Anat. In Druck.Google Scholar
  2. -Alterações ultraestruturais no cérebro de camondongos inoculados experimentalmente com Arbovirus Be An 67949. Em preparo.Google Scholar
  3. Baruch, E., Carbonell, L., Weibel, J.: Fine structure of Councilman bodies in the liver of Aluatta seniculus seniculus L infected with yellow fever virus. Exp. Cell Res.29, 50–53 (1963).PubMedCrossRefGoogle Scholar
  4. Bearcroft, W. G.: Electron microscope studies on the liver cells of yellow fever infected rhesus monkeys. J. Path. Bact.80, 421–426 (1960).PubMedCrossRefGoogle Scholar
  5. — Electron microscopic studies on the liver of yellow fever infected africans monkeys. J. Path. Bact.83, 59–64 (1962).PubMedCrossRefGoogle Scholar
  6. Bechtelsheimer, H., Korb, G., Gedigk, P.: Die „Marburg-Virus“-Hepatitis-Untersuchung bei Menschen und Meerschweinchen. Virchows Arch. Anat.A 351, 273–290 (1970).Google Scholar
  7. Berghold, G. H.: Structure of 9 arboviruses. J. gen. Virol.5, 135–140 (1969).Google Scholar
  8. Braunsteiner, H., Fellinger, R., Pakesch, P.: Über die submikroskopischen Einschlußkörper bei Hepatitis. Klin. Wschr.40, 210–211 (1962).PubMedCrossRefGoogle Scholar
  9. Councilman, W. T.: Pathologic histology of yellow fever. In: Report on etiology and prevention of yellow fever, ed. G. M. Sternberg, U. S. Marine Hosp. Service, Publ. Hlth Rep. Bull. No.2, p. 151 (1890).Google Scholar
  10. De Paola, D.: Patologia dos virus tropicais. Atas do Simpósio Biota Amazonica6 (Patol), 25–29 (1967).Google Scholar
  11. Erlandson, R. A., Babcok, V. I., Southam, C. M., Bailey, R. B., Shipkey, F. H.: Semliki forest virus in HEp-2 cell cultures. J. Virol.1, 996–1009 (1967).PubMedGoogle Scholar
  12. Griemley, P. M., Berezesky, I. K., Friedman, R. M.: Cytoplasmatic structures associated with arbovirus infections. Loci of viral ribonucleic acid synthesis. J. Virol.2, 1326–1338 (1968).Google Scholar
  13. —, Michelitch, H. J., Friedman, R. M.: Influence of subcellular organisation on the development and dissemination of an arbovirus. Amer. J. Path.59, 48a (1970).Google Scholar
  14. Gruner, J. E., Lavillauraix, J.: Sur quelques encéphalitis virales experimentales et leur histopathologie fine. Rev. neurol.108, 385–413 (1963).Google Scholar
  15. Johnson, K. P., Johnson, R. I.: California encephalitis. II. Studies of experimental infection in the mouse. J. Neuropath, exp. Neurol.27, 390–409 (1968).CrossRefGoogle Scholar
  16. Lacerda, P. R. S., De Paola, D., Bruno-Lobo, M., Bruno-Lobo, G.: Histopatologia das arboviroses do grupo C. Atas do Simposio Biota Amazonica6 (Patol), 113–115 (1967).Google Scholar
  17. Lavillauraix, J., Nezelof, C.: Les alterations cellulaires propres aux infections virales. Ann. Anat. path.15, 21–46 (1970).Google Scholar
  18. Lunger, P.D., Darlington, R. W., Granoff, A.: Cell-virus relationship in the Lucké renal adenocarcinoma: an ultrastructural study. Ann. N.Y. Acad. Sci.126, 289–314 (1965).PubMedCrossRefGoogle Scholar
  19. Matsumoto, S.: Electron microscopic studies of mouse brain infected with rabies virus. Acta. Path. jap.14, 195–198 (1964).PubMedGoogle Scholar
  20. McGavran, M. H., Easterday, B.C.: Rift Valley fever virus hepatitis. Light and electron microscopic studies in the mouse. Amer. J. Path.42, 587–607 (1963).Google Scholar
  21. Minkowitz, S., Berkovich, S.: Hepatitis produced by Coxsackie virus B 1 in adult mice. Arch, Path.89, 427–433 (1970).Google Scholar
  22. Miyamoto, K., Matsumoto, K.: The nature of the Negri body. J. Cell Biol.27, 677–682 (1965).PubMedCrossRefGoogle Scholar
  23. Morgan, C., Ellison, S. A., Rose, H. M., Moore, D. H.: Structure and development of viruses in the electron microscope. II. Vaccinia and fowl pox virus. J. exp. Med.100, 301–310 (1956).CrossRefGoogle Scholar
  24. Mussgay, M.: Growth cicle of arbovirus in vertebrate and arthropod cells. Progr. med. Virol.6, 193–267 (1964).Google Scholar
  25. — Weibel, J.: Electron microscopic and biological studies on the growth of Venezuelan equine encephalitis virus in KB cells. Virology16, 52–62 (1962).PubMedCrossRefGoogle Scholar
  26. Nii, S., Morgan, C., Rose, H. M., Hsu, K. C.: Electron microscopy of Herpes simplex virus. IV. Studies with ferritin conjugated antibodies. J. Virol.2, 1172–1184 (1968).PubMedGoogle Scholar
  27. Rabin, E. R., Jenson, A. B.: Electron microscopic studies of animal viruses with emphasis on in vivo infections. Progr. med. Virol.9, 392–450 (1967).Google Scholar
  28. —, Phillips, C. A., Melnick, J. L.: Herpes virus hepatitis in mice. Exp. molec. Path.8, 34–48 (1968).PubMedCrossRefGoogle Scholar
  29. Ruebner, B., Bramhall, J. L.: Pathology of experimental virus hepatitis in mice. Arch. Path.69, 190–198 (1960).PubMedGoogle Scholar
  30. Ruebner, B. H., Hirano, T., Slusser, R. J.: Electron microscopy of the hepatocellular and Kupfer-cell lesions of mouse hepatitis, with particular reference ot the effect of cortisone. Amer. J. Path.51, 163–189 (1967).PubMedGoogle Scholar
  31. —, Slusser, R. J.: Hepatocytes and sinusoidal lining cells in viral hepatitis. Arch. Path.86, 1–11 (1968).PubMedGoogle Scholar
  32. Scherrer, R.: Viral and host DNA synthesis in shope fibroma virus-induced cells as studied by means of high resolution autoradiography. J. Virol.2, 1418–1428 (1968).PubMedGoogle Scholar
  33. Siegert, R., Falke, D.: Elektronenmikroskopische Untersuchungen über die Entwicklung des Herpes virus hominis in Kulturzellen. Arch. ges. Virusforsch.19, 230–249 (1966).PubMedCrossRefGoogle Scholar
  34. Swartzendruber, D. C., Ma, B. I., Murphy, W. H.: Localisation of C-type virus particles in lymphoid germinal centers of L58 mice. Proc. Soc. exp. Biol. (N. Y.)126, 731–734 (1967).Google Scholar
  35. Tawara, J. T., Goodman, J. R., Imagawa, D. T., Adams, J. M.: Fine structure of cellular inclusions in experimental measles. Virology14, 410–416 (1961).PubMedCrossRefGoogle Scholar
  36. Tournier, P.: Anatomie et classification des virus. Ann. Anat. path.15, 7–20 (1970).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • F. Huth
    • 1
  • R. de Araujo
    • 2
  1. 1.Institute de Patologia Regional der Universität Para/BrasilDeutschland
  2. 2.Pathologisches Institut der Universität DüsseldorfDeutschland

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