Virchows Archiv B

, 12:360 | Cite as

Genesis of foam cells : Study in rats after administration of cloforex

  • H. Flodh
  • G. Magnusson


Genesis of foam cells was studied in a model of pulmonary lipidosis in the rat. Accumulation of foam cells was induced by a daily oral administration of 60 mg/kg cloforex for four weeks. During the experimental period there was a statistically significant increase in the number of blood monocytes. The investigation indicates that there is a relationship between pulmonary foam cells and blood monocytes and that foam cells may be derived from blood monocytes.


Foam Cell Blood Monocyte Intralipid Daily Oral Administration Toxicology Laboratory 
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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • H. Flodh
    • 1
  • G. Magnusson
    • 1
  1. 1.The Toxicology LaboratoriesAstra Pharmaceuticals ABSödertäljeSweden

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