Deposits of granular material in mitochondria
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It has been shown inin vitro experiments that isolated mitochondria are able to absorb large amounts of calcium in addition to other divalent cations if ATP has been added to the culture medium (Engström and De Luca, 1964). This absorption is accompanied by ultrastructural changes in the form of electron dense granules in the matrix of the mitochondria, much larger and more numerous than the granules usually observed in mitochondria (Greenawaltet al, 1964; Peachey, 1964; Reynolds, 1965). In addition, electron microscopic studies have disclosed similar intramitochondrial granules in osteoclasts (Gonzales, 1961), in the epithelium of the renal tubules after administration of parathyroid hormone (Gaulfield, 1964), and in liver cells after poisoning by carbon tetrachloride (Reynolds, 1965). In the latter cells an increased calcium content was also demonstrable in the mitochondrial fraction after ultracentrifugation. The object of the present paper is to describe in neoplastic cells the presence of intramitochondrial granules that are indistinguishable morphologically from those found by the above workers.
KeywordsGolgi Apparatus Granular Material Divalent Cation Uveal Melanoma Electron Dense Granule
Ablagerung granulären Materials in Mitochondrien
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- — Jensen, O. A.: Electron microscopy of melanomas of the human uveal tract: the ultrastructure of four malignant melanomas of the mixed cell type. Acta ophthal. (Kbh.)42, 665–671 (1964).Google Scholar
- Francois, J., Rabaey, M., Lagasse, A.: Examen au microscope électronique d’un sarcome de l’uvée. Bull. Soc. belge Ophtal.119, 504–513 (1958).Google Scholar
- Rabaey, M., Lagasse, A.: L’ultrastructure d’un sarcome de l’uvée. Bull. Micr. appl.9 21–25 (1959).Google Scholar