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Pathology & Oncology Research

, Volume 13, Issue 3, pp 260–262 | Cite as

Primary bone marrow T-cell anaplastic large cell lymphoma with triple m gradient

  • Árpád Szomor
  • Talal Al Saati
  • Georges Delsol
  • László Kereskai
  • Zsuzsanna Szijártó
  • Hajna Losonczy
Case Report

Abstract

We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency.

Key words

anaplastic large cell lymphoma T-cell receptor gene rearrangement immunoglobulin heavy chain gene rearrangement M gradient bone marrow 

Abbreviations

PCR

polymerase chain reaction

IgH

immunoglobulin heavy chain

TCR

T-cell receptor

RT-PCR

reverse transcriptase polymerase chain reaction

ALK

anaplastic lymphoma kinase

CHOP

cyclophosphamide-hydroxy epirubicine-oncovin-pred-nisolone

ALCL

anaplastic large cell lymphoma

HCV

hepatitis C virus

HBsAg

hepatitis B surface antigen

MDR

multi-drug resistance

WHO

World Health Organization

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Copyright information

© Arányi Lajos Foundation 2007

Authors and Affiliations

  • Árpád Szomor
    • 1
  • Talal Al Saati
    • 4
  • Georges Delsol
    • 4
  • László Kereskai
    • 2
  • Zsuzsanna Szijártó
    • 3
  • Hajna Losonczy
    • 1
  1. 1.1st Department of MedicineUniversity of PécsPécsHungary
  2. 2.Institute of PathologyUniversity of PécsHungary
  3. 3.Department of OphthalmologyUniversity of PécsHungary
  4. 4.Laboratory of Anatomic PathologyCentral Hospital University PurpanToulouseFrance

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