Follicular lymphoma with prominent sclerosis (“sclerosing variant of follicular lymphoma”) exhibiting a mesenteric bulky mass resembling inflammatory pseudotumor. Report of three cases
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We present three cases of follicular lymphoma (FL) exhibiting prominent sclerosis (sclerosing variant of follicular lymphoma), resembling inflammatory pseudotumor (IPT) of the lymph node, arising from mesenteric lymph node. Clinically all three cases represented bulky masses of the mesenteric lymph node. Histologically, the lesions were characterized by neoplastic lymphoid follicles separated by stromal collagenization and sclerotic process, with cellular infiltrate extending into the adjacent adipose tissue. The lesions contained variable cellular spindle cell proliferation and inflammatory infiltrate including numerous reactive T cells and histiocytes. Small capillary proliferation with vascular change was also noted. Immunohistochemical study demonstrated the myofibroblastic nature of the spindle cells. Moreover, neoplastic follicles were composed of intermediate to medium-sized lymphocytes, somewhat resembling reactive lymphoid aggregates. The overall histomorphological findings of the three lesions were similar to those of IPT of the lymph node. However, CD10, Bcl-2 and Bcl-6 immunostaining demonstrated the neoplastic nature of the lymphoid follicles and the lesions were diagnosed as FL grade 1. The present three cases indicate that the sclerosing variant of grade 1 FL should be added to the differential diagnosis from IPT of the lymph node.
Key wordsfollicular lymphoma sclerosis mesenterium inflammatory pseudotumor immunohistochemistry
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- 8.Warnke RF, Weiss LM, Chan JKC, Clearre ML, Dorfman RF: Tumor of the lymph nodes and spleen (Atlas of Tumor Pathology, 3rd series, Fascicle 14). Armed Forces Institute of Pathology, Bethesda MD, 1995, pp 63–118Google Scholar
- 9.Feller AC, Diebold J: Histopathology of nodal and extranodal non-Hodgkin’s lymphomas. Berlin, Springer, 2003, pp 53–66Google Scholar
- 10.Bennet MH: Sclerosis in non-Hodgkin’s lymphomata. Br J Cancer Suppl 31:44–52, 1975Google Scholar