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Indian Journal of Clinical Biochemistry

, Volume 20, Issue 1, pp 95–97 | Cite as

Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?

  • Krishnananda Prabhu
  • P. Gopalakrishna Bhat
  • D. M. Vasudevan
Article

Abstract

We conducted a pilot study wherein serum Glutathione-S-transferase levels were measured before and after radiotherapy in carcinoma cervix patients and correlated with response to treatment during a two-year follow-up period. Out of 17 patients who received radiotherapy, 9 showed a significant decrease (p<0.005) while 8 showed significant increase (p<0.004) in post radiotherapy glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that alterations in serum Glutathione-S-transferase levels may help us to predict radiation response

Key Words

Glutathione-s-transferase Radiotherapy Carcinoma cervix 

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Copyright information

© Association of Clinical Biochemists of India 2005

Authors and Affiliations

  • Krishnananda Prabhu
    • 1
  • P. Gopalakrishna Bhat
  • D. M. Vasudevan
  1. 1.Department of BiochemistryKasturba Medical CollegeManipalIndia

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