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Augmented mitogenesis in normal connective tissue cells following mast-cell secretion in diabetic rats

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Virchows Archiv B

Summary

We studied the proliferative response of fibroblasts and mesothelial cells in the mesentery of streptozotocin-diabetic rats with diabetes of 4 weeks duration, after local mast-cell secretion elicited by compound 48/80. Free peritoneal mast cells from the diabetic animals showed no altered content of 5-HT, histamine, or heparin, and the concentration of histamine in the mesentery and its release by 48/80 were roughly similar in non-diabetic and diabetic animals.

The diabetic animals showed an increased responsiveness in this strictly mast-cell dependent mitogenesis, as measured by specific DNA activity and the mitotic index, regardless of whether the animals were insulin-deficient or treated for 2 h with fast-acting insulin.

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Authors and Affiliations

  1. Department of Pathology II, University of Linköping, S-58185, Linköping, Sweden

    K. Norrby, S. Bergström & P. Druvefors

  2. Department of Internal Medicine, University of Linköping, S-58185, Linköping, Sweden

    H. J. Arnqvist

Authors
  1. K. Norrby
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  2. H. J. Arnqvist
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  3. S. Bergström
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  4. P. Druvefors
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Supported by grants from the Swedish Medical Research Council, Project no. 5942

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Norrby, K., Arnqvist, H.J., Bergström, S. et al. Augmented mitogenesis in normal connective tissue cells following mast-cell secretion in diabetic rats. Virchows Archiv B Cell Pathol 39, 137–144 (1982). https://doi.org/10.1007/BF02892843

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  • DOI: https://doi.org/10.1007/BF02892843

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