Virchows Archiv B

, 39:137 | Cite as

Augmented mitogenesis in normal connective tissue cells following mast-cell secretion in diabetic rats

  • K. Norrby
  • H. J. Arnqvist
  • S. Bergström
  • P. Druvefors


We studied the proliferative response of fibroblasts and mesothelial cells in the mesentery of streptozotocin-diabetic rats with diabetes of 4 weeks duration, after local mast-cell secretion elicited by compound 48/80. Free peritoneal mast cells from the diabetic animals showed no altered content of 5-HT, histamine, or heparin, and the concentration of histamine in the mesentery and its release by 48/80 were roughly similar in non-diabetic and diabetic animals.

The diabetic animals showed an increased responsiveness in this strictly mast-cell dependent mitogenesis, as measured by specific DNA activity and the mitotic index, regardless of whether the animals were insulin-deficient or treated for 2 h with fast-acting insulin.

Key words

Diabetes Mast cell DNA-synthesis Mitosis 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. Norrby
    • 1
  • H. J. Arnqvist
    • 2
  • S. Bergström
    • 1
  • P. Druvefors
    • 1
  1. 1.Department of Pathology IIUniversity of LinköpingLinköpingSweden
  2. 2.Department of Internal MedicineUniversity of LinköpingLinköpingSweden

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