The treatment of shigellosis I. Synergistic effect of antibiotics on shigella

  • Harry Seneca
  • Ellen Bergendahl

Summary and conclusion

  1. 1.

    Neomycin plus polymyxin in 1 to 10 ratio potentiates the inhibitory effect of neomycin and polymyxin onShigella paradysenteriac (Flexner, Boyd and Sonne) 5 to 30-fold and 25 to 70-fold respectively.

  2. 2.

    Neomycin plus streptomycin in 1 to 10 ratio potentiates the inhibitory effect of neomycin and streptomycin on Shigella 1.5 to 2.5-fold and 2.5 to 3-fold respectively.

  3. 3.

    Neomycin plus tetracycline or oxytetracycline in 1 to 10 ratio potentiates the inhibitory effect of neomycin onShigella 1.5 to 2.5-fold and 2.5 to 3-fold 3-fold.

  4. 4.

    Neomycin plus Magnamycin in 1 to 1250 ratio enhances the inhibitory effect of neomycin 1.5 to 2.5-fold, and of Magnamycin 0.5 to 8-fold, and in the same ratio, neomycin phis bacitracin enhances the effect of neomycin 2.5 to 3-fold and of bacitracin effect 1 to 2-fold.

  5. 5.

    Neomycin plus viomycin in 1 to 10 ratio results in mutual depression.



Tetracycline Neomycin Brucellosis Polymyxin Oxytetracycline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Sandfield Publishing Company 1954

Authors and Affiliations

  • Harry Seneca
    • 1
  • Ellen Bergendahl
    • 1
  1. 1.College of Physicians and SurgeonsColumbia UniversityNew York, New York

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