Advertisement

The treatment of shigellosis I. Synergistic effect of antibiotics on shigella

  • Harry Seneca
  • Ellen Bergendahl
Article

Summary and conclusion

  1. 1.

    Neomycin plus polymyxin in 1 to 10 ratio potentiates the inhibitory effect of neomycin and polymyxin onShigella paradysenteriac (Flexner, Boyd and Sonne) 5 to 30-fold and 25 to 70-fold respectively.

     
  2. 2.

    Neomycin plus streptomycin in 1 to 10 ratio potentiates the inhibitory effect of neomycin and streptomycin on Shigella 1.5 to 2.5-fold and 2.5 to 3-fold respectively.

     
  3. 3.

    Neomycin plus tetracycline or oxytetracycline in 1 to 10 ratio potentiates the inhibitory effect of neomycin onShigella 1.5 to 2.5-fold and 2.5 to 3-fold 3-fold.

     
  4. 4.

    Neomycin plus Magnamycin in 1 to 1250 ratio enhances the inhibitory effect of neomycin 1.5 to 2.5-fold, and of Magnamycin 0.5 to 8-fold, and in the same ratio, neomycin phis bacitracin enhances the effect of neomycin 2.5 to 3-fold and of bacitracin effect 1 to 2-fold.

     
  5. 5.

    Neomycin plus viomycin in 1 to 10 ratio results in mutual depression.

     

Keywords

Tetracycline Neomycin Brucellosis Polymyxin Oxytetracycline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Hardy, A. V. and J. Watt.: Acute diarrheal diseases, J. A. M. A., 124:1173, 1944.Google Scholar
  2. 2.
    Scadding, J. G.: Sulfonamides in bacillary dysentery, Lancet 2:549, 1945.CrossRefGoogle Scholar
  3. 3.
    Fairley, N. H.: Medicine in jungle warfare, Proc. Roy. Soc. Med. 38:195, 1945.Google Scholar
  4. 4.
    Long, P. H.: Clinical uses of antibiotics: IV. Treatment of infectious processes. U. S. Armed Forces Med. J. 1:1273, 1950.PubMedGoogle Scholar
  5. 5.
    Boyd, J. S. K.: Fifty years of tropical medicine, Brit. Med. J., 1:37, 1950.PubMedGoogle Scholar
  6. 6.
    Hardy, A. V.: Studies of the acute diarrheal diseases, X (C): Further cultural observations on the relative efficacy of sulfonamides in shigellosis. Pub. Health Rep. 60:1037, 1945.Google Scholar
  7. 7.
    Hardy, A. V. and S. P. Halbert: Studies on acute diarrheal diseases, XX: Efficacy of streptomycin and sulfacarzol. Pub. Health Rep. 63:790, 1948.Google Scholar
  8. 8.
    Ross, S. F. et al.: Treatment of shigella enteritis with oral streptomycin. J. A. M. A., 141:183, 1949.Google Scholar
  9. 9.
    Ross, S. F. et al.: Chloramphenicol therapy inShigella enteritis. J. A. M. A., 143:1459, 1950.Google Scholar
  10. 10.
    Lieberman, D. and E. Jawetz: Treatment ofShigella infection with polymyxin. J. Ped. 8:249, 1951.Google Scholar
  11. 11.
    Hardy, A. V., R. P. Mason, and G. A. Martin: Antibiotics in acute bacillary dysentery. Ann. N. Y. Ac. Med. 55: 1070, 1952.CrossRefGoogle Scholar
  12. 12.
    Jackson, G. G. et al.: In vitro sensitivity of pathogenic enteric bacteria to various antibiotics. J. Inf. Dis. 87:63, 1950.Google Scholar
  13. 13.
    Jawetz, E. et al.: Studies on antibiotic synergism and antagonism. Arch Int. Med., 87:349, 1951.Google Scholar
  14. 14.
    Jawetz, E. and J. B. Gunnison: Studies on antibiotic synergism and antagonism. Antibiotics & Chemotherapy. 11:243, 1952.Google Scholar
  15. 15.
    Hall, W. H. and W. W. Spink: Therapy of experimental brucella infection in developing chick embryo. J. Immunol. 59:379, 1948.PubMedGoogle Scholar
  16. 16.
    Shaffer, J. M. and W. W. Spink: Therapy of experimental brucella infection in developing chick embryo. II. Infection and therapy via yolk sac. Immunol. 59:393, 1948. III. Synergistic effect of streptomycin and sulfadiazine. J. Immunol. 60:405, 1948.PubMedGoogle Scholar
  17. 17.
    Magill, G. B. and Killough, J. H.: Oxytetracyclinestreptomycin therapy in brucellosis. Arch. Int. Med. 91: 204, 1953.Google Scholar
  18. 18.
    Shaffer, J. M. et al.: Protection of intracellular brucella against therapeutic agents and the bactericidal action of serum. J. Exp. Med. 97:77, 1953.PubMedCrossRefGoogle Scholar
  19. 19.
    Robbins, W. C. and R. Tomp’sett: Treatment of enterococcal endocarditis and bacteremia. Am. J. Med. 10:278, 1951.PubMedCrossRefGoogle Scholar
  20. 20.
    Ahern, J. J. and W. M. M. Kirby: Cure of subacute bacterial endocarditis with penicillin and chloramphenieol. J. A. M. A., 150:33, 1952.Google Scholar
  21. 21.
    Jawetz, E. et al.: Antibiotic synergism and antagonism. New Eng. J. Med., 245:966, 1951.PubMedGoogle Scholar
  22. 22.
    Johnson, B. A. and F. L. Meleney: Studies on the synergism between bacitracin and penicillin: correlation of in vivo and in vivo results. Ann. N. Y. Ac. Sc. 53:42, 1950.CrossRefGoogle Scholar
  23. 23.
    Meleney, F. L. et al.: Importance of laboratory data in the treatment of surgical infections by antibiotics: synergistic action of penicillin and bacitracin. J. Mt. Sinai Hosp., N. Y., 18:257, 1952.Google Scholar
  24. 24.
    Waring, A. J. and M. H. D. Smith: Combined penicillin and sulfonamide therapy in the treatment of pneumoeoccic meningitis. J. A. M. A., 126:418, 1944.Google Scholar
  25. 25.
    Zinneman, K.: A survey of the outcome of 20 cases of H. influenzae meningitis related to bacterial type. Brit. Med. J. 2:931, 1946.CrossRefGoogle Scholar

Copyright information

© Sandfield Publishing Company 1954

Authors and Affiliations

  • Harry Seneca
    • 1
  • Ellen Bergendahl
    • 1
  1. 1.College of Physicians and SurgeonsColumbia UniversityNew York, New York

Personalised recommendations