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Длительная иммуниза ция. II.

Изменения в перитоне альном экссудате, лей коцитарной и температурной реак ции
  • Jaroslav Šterzl
Article
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Резюме

У животных, у которых в результате полугодо вой ежедневной иммуниза ции была подавлена способность к образо ванию антител, исслед овались (после введения иммун изирующей дозы) интенсивность и зменений количества лейкоцитов в периферической кро ви и в перитонеальном экссудате и интенсив ность температурной реакции. Опыты показали, что эт и реакции на введение а нтигена полностью со храняются и в период угнетения об разования антител. Мы не находил и, что эти реакции сохр анялись бы в ревультате выработ авшейся временной условной с вязи, — за исключением реакции в перитонеальном эксс удате: напротив, они вызываются непос редственно раздража ющим действием антигена. П оэтому мы делаем вывод, что сниж ение способности к об разованию антител в результате длительной ежедневной иммуниза ции не следует рассма тривать как снижение общей реакт ивности организма, каким явля ется ‘иммунологичес кое торможение’, ибо сущн ость изменений: заключается в специф ических процессах об разования антител.

Dlouhodobá imunisace. II

Long-term immunisation. II

Změny peritoneálního exsudátu, reakce leukocytární a teplotové
Changes in the peritoneal exudate, leucocytic and temperature reactions

Souhrn

U zvířat, u kterých se po kazdodenní půlroční imunisaci utlumila tvorba protilátek, byla sledována po imunisační dávce intensita změn leukocytů v periferní krvi, v peritoneálním exsudátu a intensita teplotové reakce.

Pokusy ukázaly, ze tyto odpovědi jsou po vpravení antigenu-v době útlumu tvorby protilátek—plně zachovány.

Nezjistili jsme — s výjimkou reakce v peritoneálním exsudátu — ze by zachované odpovědi byly výsledkem vytvořeného podmíněného spojeni; jsou působeny přimým drázdivým vlivem antigenu.

Uzaviráme proto, ze snízení tvorby protilátek po kazdodenní dlouhodobé imunisaci neni mozno posuzovat jako snízení obecné reaktivnosti organisrau, jako „imunologický útlum“, ale ze podstatou jsou změny ve specifických pochodech tvorby protilátek.

Summary

The intensity of leucocytic changes in the peripheral blood, in the peritoneal exudate and the intensityof temperature reactions following an immunisation dose was studied in animals in which, after daily immunisation for half a year, the formation of antibodies had been depressed. The experiments showed that, after administration of the antigen—in the period of depression of antibody formation—these responses are fully preserved. It was not found (with the exception of the reaction in the peritoneal exudate) that the preserved responses were the result of the formation of a conditioned association; they are caused by the direct irritant action of the antigen. It is therefore concluded that the decrease in the formation of antibodies following prolonged, daily immunisation cannot be evaluated as a decrease in the general reactivity of the organism, like “immunological depression”, but that it is based on. changes in specific processes of antibody formation.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1956

Authors and Affiliations

  • Jaroslav Šterzl
    • 1
  1. 1.Biologický ůstav, mikrobiologické odděleníČeskoslovenská akademie vědPraha

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