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Epithelial cell population kinetics of the small intestine after ileo-jejunal transposition

Autoradiographic studies in the rat

  • Published:
Virchows Archiv B

Summary

Sixty days after ileo-jejunal transposition epithelial cell population kinetics of the small intestine were investigated by autoradiography with H3-thymidine in the rat. Controls were subjected to transection and anastomosis at three sites equivalent to those used in transposition. Increases occurred in both transposed segments in the sizes of the crypt cell population (P<0.01) and of the proliferative zone (P<0.05). The relative sizes of the proliferative and maturation zones were unchanged. A pattern of decreasing villous size was re-established in a duodeno-ileal direction. The size of the villous zone in the transposed ileal segment exceeded that of control jejunum (P< 0.002) but the villous zone in the transposed jejunal segment was similar to that of control ileum. The difference in villous zone size between transposed segments seems to be regulated by a factor (s) other than the increase in crypt cell proliferation which was of similar magnitude in each segment.

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References

  • Altmann, G.G.: Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat. Am. J. Anat.132, 167–178 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Altmann, G.G., Enesco, M.: Cell number as a measure of distribution and renewal of epithelial cells in the small intestine of growing and adult rats. Am. J. Anat.121, 319–336 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Altmann, G.G., Leblond, C.P.: Factors influencing villus size in the small intestine of adult rats as revealed by transposition of intestinal segments. Am. J. Anat.127, 15–36 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Dowling, R.H., Booth, C.C.: Structural and functional changes following small intestinal resection in the rat. Clin. Sci.32, 139–149 (1967)

    PubMed  CAS  Google Scholar 

  • Feldman, E.J., Dowling, R.H., McNaughton, J., Peters, T.J.: Effects of oral versus intravenous nutrition on intestinal adaptation after small bowel resection in the dog. Gastroenterology70, 712–719 (1976)

    PubMed  CAS  Google Scholar 

  • Gronquist, B., Engstrom, B., Grimelius, L.: Morphological studies of the rat small intestine after jejuno-ileal transposition. Acta Chir. Scand.141, 208–217 (1975)

    Google Scholar 

  • Hanson, W.R., Osborne, J.W.: Epithelial cell kinetics in the small intestine of the rat 60 days after resection of 70 per cent of the ileum and jejunum. Gastroenterology60, 1087–1097 (1971)

    PubMed  CAS  Google Scholar 

  • Hanson, W.R., Rijke, R.P.C., Plaisier, H.M., Van Ewijk, W., Osborne, J.W.: The effect of intestinal resection on Thiry-Vella fistulae of jejunal and ileal origin in the rat: Evidence for a systemic control mechanism of cell renewal. Cell Tiss. Kinet.10, 543–555 (1977)

    CAS  Google Scholar 

  • Levine, G.M., Deren, J.J., Steiger, E., Zinno, R.: Role of oral intake in maintenance of gut mass and disaccharide activity. Gastroenterology67, 975–982 (1974)

    PubMed  CAS  Google Scholar 

  • Loran, M.R., Carbone, J.V.: The humoral effect of intestinal resection on cellular proliferation and maturation in parabiotic rats. In: Monographs in nuclear medicine and biology No. 1. Gastrointestinal radiation injury, M.F. Sullivan (ed.), 127–141. Amsterdam: Excerpta Medica Foundation 1968

    Google Scholar 

  • McDermott, F.T., Dalton, M.K., Galbraith, M.B.: Ileal epithelial cell migration in acute renal failure. Autoradiographic studies in the mouse. Am. J. Dig. Dis.19, 1116–1119 (1974)

    Article  PubMed  CAS  Google Scholar 

  • McDermott, F.T., Roudnew, B.: Ileal crypt cell population kinetics after 40% small bowel resection: Autoradiographic studies in the rat. Gastroenterology70, 707–711 (1976)

    PubMed  CAS  Google Scholar 

  • McDermott, F.T., Roudnew, B.: Ileal epithelial cell migration after 40% small bowel resection: Autoradiographic studies in the rat. Am. J. Dig. Dis.22, 637–640 (1977)

    Article  PubMed  CAS  Google Scholar 

  • McDermott, F.T., Roudnew, B.: Epithelial cell population kinetics of isolated ileal loops (Thiry-Vella fistulae) after 40% small intestinal resection. Autoradiographic studies in the rat. Virchows Arch. B Cell Path.28, 179–185 (1978)

    CAS  Google Scholar 

  • Rijke, R.P.C., Hanson, W.R., Plaisier, H.M.: The effect of transposition to jejunum on epithelial cell kinetics in an ileal segment. Cell Tiss. Kinet.10, 399–406 (1977)

    CAS  Google Scholar 

  • Tilson, M.D., Wright, H.K.: Adaptation of functioning and bypassed segments of ileum during compensatory hypertrophy of the gut. Surgery67, 687–693 (1970)

    PubMed  CAS  Google Scholar 

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McDermott, F.T. Epithelial cell population kinetics of the small intestine after ileo-jejunal transposition. Virchows Archiv B Cell Pathol 31, 1–6 (1979). https://doi.org/10.1007/BF02889916

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  • DOI: https://doi.org/10.1007/BF02889916

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