Epithelial cell population kinetics of the small intestine after ileo-jejunal transposition
Sixty days after ileo-jejunal transposition epithelial cell population kinetics of the small intestine were investigated by autoradiography with H3-thymidine in the rat. Controls were subjected to transection and anastomosis at three sites equivalent to those used in transposition. Increases occurred in both transposed segments in the sizes of the crypt cell population (P<0.01) and of the proliferative zone (P<0.05). The relative sizes of the proliferative and maturation zones were unchanged. A pattern of decreasing villous size was re-established in a duodeno-ileal direction. The size of the villous zone in the transposed ileal segment exceeded that of control jejunum (P< 0.002) but the villous zone in the transposed jejunal segment was similar to that of control ileum. The difference in villous zone size between transposed segments seems to be regulated by a factor (s) other than the increase in crypt cell proliferation which was of similar magnitude in each segment.
Key wordsCell division Intestinal mucosa Small intestine
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