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Virchows Archiv B

, 50:293 | Cite as

In vitro interactions of murine peritoneal macrophages and sarcoma cells

II. Induction of DNA synthesis in macrophages
  • Barbara Plytycz
  • Sigrun Espelid
  • Tore Gauperaa
  • Trond Eskeland
  • Rolf Seljelid
Article

Summary

Unstimulated peritoneal macrophages grown in vitro for 5 days do not incorporate thymidine. Sarcoma (AA) cells introduced to the culture on the fifth day die and disintegrate whereas the macrophages become markedly stimulated and autoradiography shows that they are triggered to synthesize DNA. In syngeneic cocultures up to 28% of the macrophages incorporate thymidine after 5 days of coculture.

Key words

Macrophage DNA synthesis Sarcoma In vitro 

References

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Barbara Plytycz
    • 1
    • 2
  • Sigrun Espelid
    • 1
  • Tore Gauperaa
    • 1
  • Trond Eskeland
    • 1
  • Rolf Seljelid
    • 1
  1. 1.Institute of Medical BiologyUniversity of TromsøTromsøNorway
  2. 2.Department of Comparative AnatomyJagiellonian UniversityKrakówPoland

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