Mechanism of hematuria
- 79 Downloads
Masugi nehpritis was induced in Sprague-Dawley rats by an intravenous injection of rabbit anti-rat kidney serum. In the autologous phase of the disease, three of 18 rats manifested continuous hematuria. Ultrastructural examination of renal glomeruli by transmission and scanning microscopy revealed gaps in the basement membranes, and the transcapillary passage of red blood cells through the discontinuous regions in the hematuric rats. Control animals revealed no gaps in the glomerular basement membranes regardless of the method used in their preparation for electron microscopy. These data support the hypothesis that hematuria is a result of the passage of red blood cells through gaps in the glomerular basement membrane in Masugi nephritis.
Key wordsHematuria Nephrotoxic nephritis Glomerular basement membrane Acellular kidney Scanning electron microscopy
- Brendel K, Meezan E, Nagle RB (1978) The acellular perfused kidney, A model for basement membrane permeability. In: Kefalides NA (ed) Biology and chemistry of basement membranes. Academic Press, Philadelphia, pp 177–193Google Scholar
- Fliegel SEG, Lee EC, McCoy JP, Johnson KJ, Varani J (1984) Protein degradation following treatment with hydrogen peroxide. Am J Pathol 115:418–425Google Scholar
- Györkey F, Min K, O’Neal RM, Györkey MA (1968) The glomeruli in nephritis of Schönlein-Henoch syndrome. Ultrastructural observations in adult patients. Lab Invest 18:324Google Scholar
- Shigematsu H, Kobayashi Y (1971) The development and fate of the immune deposits in the glomerulus during the secondary phase of rat Masugi Nephritis. Virchows Arch [Cell Pathol] 8:38–95Google Scholar