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Virchows Archiv B

, 50:199 | Cite as

Mechanism of hematuria

I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis
  • Hirofumi Makino
  • Shigeaki Nishimura
  • Kenji Soda
  • Michio Takaoka
  • Tetsuji Kaneshige
  • Zensuke Ota
Article

Summary

Masugi nehpritis was induced in Sprague-Dawley rats by an intravenous injection of rabbit anti-rat kidney serum. In the autologous phase of the disease, three of 18 rats manifested continuous hematuria. Ultrastructural examination of renal glomeruli by transmission and scanning microscopy revealed gaps in the basement membranes, and the transcapillary passage of red blood cells through the discontinuous regions in the hematuric rats. Control animals revealed no gaps in the glomerular basement membranes regardless of the method used in their preparation for electron microscopy. These data support the hypothesis that hematuria is a result of the passage of red blood cells through gaps in the glomerular basement membrane in Masugi nephritis.

Key words

Hematuria Nephrotoxic nephritis Glomerular basement membrane Acellular kidney Scanning electron microscopy 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Hirofumi Makino
    • 1
  • Shigeaki Nishimura
    • 1
  • Kenji Soda
    • 1
  • Michio Takaoka
    • 1
  • Tetsuji Kaneshige
    • 2
  • Zensuke Ota
    • 1
  1. 1.Third Department of MedicineOkayama University Medical SchoolJapan
  2. 2.Okayama Central Hospital LaboratoryOkayamaJapan

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