Virchows Archiv B

, 45:75 | Cite as

Amyloid P component in human thyroid

  • C. H. Kendall
  • F. Walker


The distribution of amyloid P component in the adult human thyroid was studied by direct immunofluorescence on frozen sections of surgically removed tissue. Amyloid P component shows a striking fibrillary and broken linear distribution in the interfollicular areas. This pattern corresponds to that of reticulin fibres. Amyloid P is also localised to the small amount of elastic tissue in blood vessels but is not demonstrable within cells or in acinar basement membranes.

Key words

Amyloid P component Thyroid Reticulin 


  1. Breathnach SM, Bhogal B, Dyck RF, Beer FC de, Black MM, Pepys MB (1981a) Immunohistochemical demonstration of amyloid P component in skin of normal subjects and patients with cutaneous amyloidosis. Br J Dermatol 105:115–124PubMedCrossRefGoogle Scholar
  2. Breathnach SM, Melrose SM, Bhogal B, Beer FC de, Dyck RF, Tennent G, Black MM, Pepys MB (1981b) Amyloid P component is located on elastic fibre microfibrils in normal human tissue. Nature 293:652–654PubMedCrossRefGoogle Scholar
  3. Clayton SJ, Walker F (1983) The distribution of amyloid P component in normal human cervix. Virchows Arch [Cell Pathol] 43:63–66CrossRefGoogle Scholar
  4. Dyck RF, Lockwood CM, Kershaw M, McHugh N, Duance VC, Baltz ML, Pepys M (1980) Amyloid P component is a constituent of normal human glomerular basement membrane. J Exp Med 152:1162–1174PubMedCrossRefGoogle Scholar
  5. Hamon MD, Walker F (1982) The distribution of amyloid P component in normal human skin. Virchows Arch [Cell Pathol] 40:411–415Google Scholar
  6. Hoick M, Husby G, Sletten K, Matvig JB (1979) The amyloid P component: an integral part of amyloid substance. Scand J Immunol 10:55–60CrossRefGoogle Scholar
  7. Pras M, Glynn LE (1973) Isolation of a non-collagenous reticulin component and its primary characterisation. Br J Exp Pathol 54:449–456PubMedGoogle Scholar
  8. Schneider HM, Loos M (1978) Amyloid P component-a special type of collagen? Virchows Arch [Cell Pathol] 29:225–228Google Scholar
  9. Unsworth DJ, Scott DL, Almond TJ, Beard HK, Holborow EJ, Walton KW (1982) Studies on reticulin. Br J Exp Pathol 63:154–166PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • C. H. Kendall
    • 1
  • F. Walker
    • 1
  1. 1.Department of PathologyUniversity of LeicesterLeicesterGreat Britain

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